Risk for non-sentinel metastases in the contralateral groin in patients with a unilateral positive sentinel lymph node in primary vulvar cancer- a subgroup analysis of the AGO-VOP.2 QS Vulva Study

Jaeger A, Hampl M, Prieske K, Eulenburg C, Reichenbach J, Klapdor R, Heublein S, Schochter F, Gaß P, Rohner A, Canzler U, Becker S, Bommert M, Bauerschlag D, Denecke A, Hanker L, Runnebaum I, Forner DM, Klar M, Schwab R, Koepke M, Kalder M, Hantschmann P, Ratiu D, Denschlag D, Schroeder W, Tuschy B, Baumann K, Mustea A, Soergel P, Bronger H, Bauerschmitz G, Kosse J, Koch MC, Ignatov A, Sehouli J, Dannecker C, Schmalfeldt B, Mahner S, Woelber L (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Book Volume: 200

Pages Range: 8-13

DOI: 10.1016/j.ygyno.2025.07.003

Abstract

The need for contralateral full groin dissection after bilateral sentinel node biopsy (SNB) with only unilateral detection of a macrometastasis is still a matter of debate. GROINSS-VI/II subanalysis has shown an absolute risk <3 % for contralateral groin recurrence or contralateral non-sentinel metastases, however, the individual risk varied widely dependent on the primary tumor characteristics. Methods: The AGO VOP.2 QS vulva study is a retrospective, multicenter study. Data from 306 patients diagnosed with primary groin node positive VSCC (vulvar squamous cell carcinoma) between 2017 and 2019 at 33 gynecologic cancer centers in Germany were collected. In the current subgroup analysis, only patients with bilateral SNB and unilateral positive SNL were included. Results: Of 306 documented groin node positive patients, 137 received bilateral SNB. Of these, 98 had a unilaterally positive SNL. The consecutive contralateral groin procedure was at the surgeons' discretion. 58/98 (59.2 %) received a bilateral inguinofemoral lymphadenectomy (if-LAE). 30/98 (30.6 %) underwent ipsilateral if-LAE only and 10/98 (10.2 %) had no further surgical treatment of the groins. 3/98 (3.1 %) patients either showed contralateral non-SN metastasis after bilateral if-LAE (n = 2) or developed isolated contralateral groin recurrence after unilateral if-LAE dissection (n = 1). Conclusion: In this large multicenter retrospective study the risk of contralateral groin recurrence was low (3,1 %). Therefore, morbidity should be carefully balanced against oncologic safety and omission of contralateral LAE should be considered.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Klinikum der Universität München Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Albertinen-Krankenhaus Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Tübingen Germany (DE) Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Kliniken Essen-Mitte Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Jena Germany (DE) Evangelisches Krankenhaus Kalk Germany (DE) Universitätsklinikum Freiburg Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Universitätsklinikum Augsburg Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Universitätsklinikum Köln Germany (DE) Hochtaunus-Kliniken Germany (DE) Universitätsklinikum Mannheim Germany (DE) Universitätsklinikum Bonn Germany (DE) Johannes Wesling Klinikum Minden Germany (DE) Technische Universität München (TUM) Germany (DE) Universitätsklinikum Göttingen Germany (DE) Sana Kliniken AG Germany (DE) Universitätsklinikum Magdeburg A.ö.R. Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE)

How to cite

APA:

Jaeger, A., Hampl, M., Prieske, K., Eulenburg, C., Reichenbach, J., Klapdor, R.,... Woelber, L. (2025). Risk for non-sentinel metastases in the contralateral groin in patients with a unilateral positive sentinel lymph node in primary vulvar cancer- a subgroup analysis of the AGO-VOP.2 QS Vulva Study. Gynecologic Oncology, 200, 8-13. https://doi.org/10.1016/j.ygyno.2025.07.003

MLA:

Jaeger, Anna, et al. "Risk for non-sentinel metastases in the contralateral groin in patients with a unilateral positive sentinel lymph node in primary vulvar cancer- a subgroup analysis of the AGO-VOP.2 QS Vulva Study." Gynecologic Oncology 200 (2025): 8-13.

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