Biocompatibility and antibacterial activity of radiopaque bismuth-containing bioactive glasses

Clavijo-Mejía GA, Michálek M, Arango Ospina M, Unalan I, Nawaz Q, Galusek D, Boccaccini AR (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Ceramics International Elsevier

DOI: 10.1016/j.ceramint.2025.07.016

Abstract

Radiopacity can be enhanced in bioactive glasses (BGs) by incorporating oxides such as Bi2O3. However, Bi effects on cell and bacterial activity remain under investigation. This study evaluates the in-vitro performance of 45S5 BG with enhanced radiopacity achieved through the progressive addition of Bi2O3. BGs were prepared using a melt-quenching method. Adding 11.5 wt % of Bi2O3 increased the radiopacity 3.4 times compared to an undoped BG. Cytocompatibility was assessed using MG-63 cells via direct and indirect methods, demonstrating similar viability across all compositions. The addition of 6 wt % of Bi2O3 induced Vascular Endothelial Growth Factor secretion. Antibacterial activity was evaluated against Gram-positive and Gram-negative bacteria strains, showing enhanced effects in both direct and indirect tests relative to undoped BGs. Results indicate that increasing Bi2O3 content improves radiopacity while maintaining or enhancing biological performance, suggesting potential applications in bone regeneration. Long-term biological effects of Bi remain to be investigated.

Authors with CRIS profile

Marcela Arango Ospina Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Qaisar Nawaz Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Trenčianska univerzita Alexandra Dubčeka v Trenčíne SK Slovakia (SK)

How to cite

APA:

Clavijo-Mejía, G.A., Michálek, M., Arango Ospina, M., Unalan, I., Nawaz, Q., Galusek, D., & Boccaccini, A.R. (2025). Biocompatibility and antibacterial activity of radiopaque bismuth-containing bioactive glasses. Ceramics International. https://doi.org/10.1016/j.ceramint.2025.07.016

MLA:

Clavijo-Mejía, G. A., et al. "Biocompatibility and antibacterial activity of radiopaque bismuth-containing bioactive glasses." Ceramics International (2025).

BibTeX: Download