Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery
Buchete NV, Cicha I, Dutta S, Neofytou P (2024)
Publication Language: English
Publication Type: Journal article, Review article
Publication year: 2024
Journal
Book Volume: 4
Article Number: 1362660
DOI: 10.3389/fddev.2024.1362660
Abstract
A rational design of drug nanocarriers supported by in silico modelling tools can improve the efficacy of nanosystem-based intravascular drug delivery (IVDD). Computational model development stems from the vision of replacing conventional (pre)clinical trials with advanced simulations and applies to the development of more efficient nanocarriers for intravascular therapies. To establish a standardized framework for in silico preclinical trials, it is necessary to include in silico tools that can model each experimental stage of a preclinical trial for a respective nanocarrier system and give accurate and verifiable results. This review paper highlights the status of intravascular drug delivery supported by nanocarriers and discusses the modelling stages of a physics-based multiscale modelling framework that should be developed, validated and exploited to address the need for an effective preclinical assessment of nanocarriers for IVDD.
Authors with CRIS profile
Involved external institutions
University College Dublin (UCD)
Ireland (IE)
National Centre for Scientific Research (NCSR) "Demokritos"
Greece (GR)
Ireland (IE)
National Centre for Scientific Research (NCSR) "Demokritos"
Greece (GR)
How to cite
APA:
Buchete, N.V., Cicha, I., Dutta, S., & Neofytou, P. (2024). Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery. Frontiers in Drug Delivery, 4. https://doi.org/10.3389/fddev.2024.1362660
MLA:
Buchete, Nicolae Viorel, et al. "Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery." Frontiers in Drug Delivery 4 (2024).
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