Pathology of ovarian cancer Pathologie des Ovarialkarzinoms
Erber R (2025)
Publication Type: Journal article, Review article
Publication year: 2025
Journal
DOI: 10.1007/s00761-025-01740-1
Abstract
Background: Ovarian cancer comprises a heterogeneous group of malignant epithelial tumors with substantial differences in histology, molecular pathology, and therapeutic options. Objective: This review describes the histopathological and molecular characteristics of the most common ovarian cancers, with a particular focus on clinically relevant diagnostic and therapeutic aspects. Materials and methods: The review comprises a systematic presentation of the major histological subtypes based on the current literature pertaining to pathogenesis, morphology, immunohistochemical profiles, and molecular biomarkers and their clinical significance. Results: Low-grade serous ovarian cancers exhibit low-grade morphology and p53-wildtype patterns, whereas high-grade serous ovarian cancers are characterized by TP53 mutations and frequent homologous recombination deficiency (HRD). Mucinous carcinomas frequently show KRAS and ERBB2 alterations; endometrioid carcinomas can be divided into prognostic molecular subgroups. Clear cell carcinomas typically harbor ARID1A and PIK3CA mutations. Biomarkers such as HER2, FRα, and HRD offer new therapeutic opportunities. Conclusion: The combination of histopathological, immunohistochemical, and molecular pathological parameters is essential for precise diagnosis and increasingly enables personalized therapeutic approaches in ovarian cancer.
Involved external institutions
Germany (DE)How to cite
APA:
Erber, R. (2025). Pathology of ovarian cancer Pathologie des Ovarialkarzinoms. Die Onkologie. https://doi.org/10.1007/s00761-025-01740-1
MLA:
Erber, Ramona. "Pathology of ovarian cancer Pathologie des Ovarialkarzinoms." Die Onkologie (2025).
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