Models of Rheumatoid Arthritis

Grötsch B, Bozec A, Schett G (2025)

Publication Language: English

Publication Type: Book chapter / Article in edited volumes

Publication year: 2025

Journal

Methods in Molecular Biology Humana Press

Publisher: Humana Press Inc.

Edited Volumes: Bone Research Protocols

Series: Methods in Molecular Biology

City/Town: New York, NY

Book Volume: 2885

Pages Range: 345-357

DOI: 10.1007/978-1-0716-4306-8_18

Abstract

Mice models induced by immunization are used to study rheumatoid arthritis (RA) and its molecular mechanisms. In this article, we describe three models that mimic the clinical symptoms of human RA and can be applied to genetically modified mice. The collagen-induced arthritis (CIA), K/BxN serum-induced arthritis (SIA), and antigen-induced arthritis (AIA) models will be presented. To achieve this, we will describe their method of induction and how to analyze RA clinical scores and pathology characteristics. Finally, we will briefly discuss the main features and drawbacks of all three models.

Authors with CRIS profile

Bettina Grötsch Department of Medicine 3 – Rheumatology and Immunology Aline Bozec Professur für Experimentelle Immuntherapie Georg Schett Lehrstuhl für Innere Medizin III

How to cite

APA:

Grötsch, B., Bozec, A., & Schett, G. (2025). Models of Rheumatoid Arthritis. In Aymen I. Idris (Eds.), Bone Research Protocols. (pp. 345-357). New York, NY: Humana Press Inc..

MLA:

Grötsch, Bettina, Aline Bozec, and Georg Schett. "Models of Rheumatoid Arthritis." Bone Research Protocols. Ed. Aymen I. Idris, New York, NY: Humana Press Inc., 2025. 345-357.

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