Advances in precision medicine in imaging and therapeutic strategies for psoriatic disease

Witte T, Minopoulou I, Drzeniek NM, Torgutalp M, Sabat R, Casteleyn V, Albach F, Fagni F, Schett G, Zabotti A, Krönke G, McGonagle D, Köhm M, Behrens F, Kleyer A, Simon D (2025)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2025

Journal

Autoimmunity Reviews Elsevier

Book Volume: 24

Article Number: 103839

Journal Issue: 8

DOI: 10.1016/j.autrev.2025.103839

Abstract

Psoriatic disease, encompassing psoriasis (PsO) and psoriatic arthritis (PsA), affects approximately 2 % of the global population. In the majority of cases, skin alterations occur first, followed by musculoskeletal disorders. The transition from cutaneous to synovio-entheseal disease reflects a gradual immune-driven progression from localized to systemic manifestations in most cases. Subclinical or non-specific symptoms often precede demonstrable synovitis or enthesitis, which further delays diagnosis and increases the risk of irreversible structural damage. Despite the critical importance of early detection, established risk factors for PsA are largely nonspecific, presenting challenges for precision medicine. Key amongst these is the presence of arthralgia, which usually precedes PsA development but is also common in degenerative and biomechanical problems. Recent advancements, encompassing cutting-edge imaging modalities, hold the potential to facilitate earlier and more precise detection of PsA, while groundbreaking therapeutic innovations are redefining treatment paradigms and may further integrate advanced imaging into personalized therapeutic strategies. This review explores the molecular and clinical complexity of psoriatic disease, highlights the latest developments in imaging and treatment, and considers their potential to revolutionize patient outcomes. Novel strategies promise advances in precision medicine and may pave the way for customized interventions that not only enhance the diagnosis and prognosis of psoriatic disease but also refine therapeutic decision-making. Innovative imaging techniques are essential to distinguishing psoriatic disease-related pain from alternative causes such as osteoarthritis, thereby guiding treatment continuation and optimization.

Authors with CRIS profile

Filippo Fagni Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE) University of Leeds GB United Kingdom (GB) Fraunhofer-Institut für Translationale Medizin und Pharmakologie (ITMP) / Fraunhofer Institute for Translational Medicine and Pharmacology DE Germany (DE) Ospedale Santa Maria della Misericordia di Udine IT Italy (IT)

How to cite

APA:

Witte, T., Minopoulou, I., Drzeniek, N.M., Torgutalp, M., Sabat, R., Casteleyn, V.,... Simon, D. (2025). Advances in precision medicine in imaging and therapeutic strategies for psoriatic disease. Autoimmunity Reviews, 24(8). https://doi.org/10.1016/j.autrev.2025.103839

MLA:

Witte, Thorben, et al. "Advances in precision medicine in imaging and therapeutic strategies for psoriatic disease." Autoimmunity Reviews 24.8 (2025).

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