Remission Period in Children With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic-Results From the DPV Registry
Lahn V, Tittel SR, Ohlenschläger U, Kamrath C, Hammersen J, Gellai R, Mönkemöller K, Dost A, Bartelt H, Holl RW (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 2025
Article Number: 9903467
Journal Issue: 1
DOI: 10.1155/pedi/9903467
Abstract
To investigate whether the remission period in type 1 diabetes, as measured by insulin-dose adjusted A1c (IDAA1C), was affected by the COVID-19 pandemic. Data from 7603 children and adolescents with type 1 diabetes from the prospective diabetes follow-up (DPV) registry were available. We compared two time periods of diabetes onset, 2020/2021 vs. 2018/2019. IDAA1C and remission prevalence (IDAA1c < 9%) were analyzed using logistic and linear regression models adjusted for age groups (0.5–<6, 6–<12, and 12–<18 years), sex, diabetic ketoacidosis (DKA) at onset, use of continuous glucose monitoring (CGM) systems, insulin pumps, sensor-augmented pumps (SAPs) or automated insulin delivery (AID) systems, BMI categories (<90. percentile of BMI, 90. −<97. percentile of BMI, 97. −<99.5 percentile of BMI, > = 99.5 percentile of BMI) and immigrant background. Data from three time periods were analyzed: 3–5 months, 6–10 months, and 11–13 months after diagnosis of type 1 diabetes. Compared to the prepandemic period, during the COVID-19 pandemic adjusted IDAA1C was significantly higher at 3–5 months after diagnosis (mean estimated differences 0.26 [95% confidence interval 0.17; 0.35], p < 0.001), but not at 6–10 months and 11–13 months after diagnosis (mean estimated difference 0.08 [−0.01; 0.17], p = 0.07; and –0.03 [−0.12; 0.07], p = 0.60), reflecting a lower percentage of patients in remission at 3–5 months. Reasons may be changes in autoimmune progression during the pandemic, lack of physical activities, increased stress or psychological burden, or altered access to care with delayed diagnosis of diabetes. Underlying causes need to be evaluated in future studies.
Involved external institutions
Altonaer Kinderkrankenhaus (AKK)
Germany (DE)
Friedrich-Ebert-Krankenhaus Neumünster
Germany (DE)
Wiener Gesundheitsverbund Kliniken
Austria (AT)
Universitätsklinikum Köln
Germany (DE)
Universitätsklinikum Jena
Germany (DE)
Universität Ulm
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Universitätsklinikum Leipzig
Germany (DE)
Germany (DE)
Friedrich-Ebert-Krankenhaus Neumünster
Germany (DE)
Wiener Gesundheitsverbund Kliniken
Austria (AT)
Universitätsklinikum Köln
Germany (DE)
Universitätsklinikum Jena
Germany (DE)
Universität Ulm
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Universitätsklinikum Leipzig
Germany (DE)
How to cite
APA:
Lahn, V., Tittel, S.R., Ohlenschläger, U., Kamrath, C., Hammersen, J., Gellai, R.,... Holl, R.W. (2025). Remission Period in Children With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic-Results From the DPV Registry. Pediatric Diabetes, 2025(1). https://doi.org/10.1155/pedi/9903467
MLA:
Lahn, Valentina, et al. "Remission Period in Children With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic-Results From the DPV Registry." Pediatric Diabetes 2025.1 (2025).
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