3D printing of PCL-based composite scaffolds coated with mesoporous bioactive glass nanoparticles (MBGNs) incorporating boron and molybdenum for ion-assisted bone tissue engineering
Nawaz Q, López GB, Strunk T, Damiani C, Mas-Moruno C, Westhauser F, Michalek M, Mutlu N, Boccaccini AR (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 60
Pages Range: 7924-7941
Article Number: 110909
Journal Issue: 19
DOI: 10.1007/s10853-025-10900-y
Abstract
A new family of composite scaffolds based on polycaprolactone (PCL) and mesoporous bioactive glass nanoparticles (MBGNs) were 3D-printed. These printed scaffolds were further coated by boron and molybdenum doped MBGNs. The scaffolds were characterized in terms of microstructure, hydrophilicity, bioactivity and cytocompatibility. The scaffolds exhibited well-defined pore geometries characterized by layer-by-layer microscale struts. MBGNs coatings increased the hydrophilicity of the PCL scaffolds. A burst release of silicon within the first 48 h (100 ppm cumulative) was observed, indicating the fast dissolution/degradation of MBGNs. In contrast, the release of other ions such as calcium, boron and molybdenum was found to be lower, which is associated with their lower doping levels in the MBGNs silica matrix. In vitro experiments showed that MBGNs (doped and non-doped) enhanced the adhesion and proliferation of MC3T3-E1 cells; these positive biological outcomes were correlated with the release and biological activity of inorganic ions. The results thus demonstrate the potential of the composite scaffolds as suitable candidates for bone tissue engineering.
Authors with CRIS profile
Qaisar Nawaz
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Trenčianska univerzita Alexandra Dubčeka v Trenčíne
Slovakia (SK)
Technische Hochschule Lübeck (THL) / Technical University of Applied Sciences Lübeck
Germany (DE)
Polytechnic University of Catalonia / Universitat Politècnica de Catalunya · BarcelonaTech (UPC) / Universidad Politécnica de Cataluña
Spain (ES)
Universität Regensburg
Germany (DE)
Slovakia (SK)
Technische Hochschule Lübeck (THL) / Technical University of Applied Sciences Lübeck
Germany (DE)
Polytechnic University of Catalonia / Universitat Politècnica de Catalunya · BarcelonaTech (UPC) / Universidad Politécnica de Cataluña
Spain (ES)
Universität Regensburg
Germany (DE)
How to cite
APA:
Nawaz, Q., López, G.B., Strunk, T., Damiani, C., Mas-Moruno, C., Westhauser, F.,... Boccaccini, A.R. (2025). 3D printing of PCL-based composite scaffolds coated with mesoporous bioactive glass nanoparticles (MBGNs) incorporating boron and molybdenum for ion-assisted bone tissue engineering. Journal of Materials Science, 60(19), 7924-7941. https://doi.org/10.1007/s10853-025-10900-y
MLA:
Nawaz, Qaisar, et al. "3D printing of PCL-based composite scaffolds coated with mesoporous bioactive glass nanoparticles (MBGNs) incorporating boron and molybdenum for ion-assisted bone tissue engineering." Journal of Materials Science 60.19 (2025): 7924-7941.
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