Disconnective Approach Leads to Superior Seizure Outcome Compared to Other Hemispheric Procedures—A Meta-Analysis
Puhahn-Schmeiser B, Höller Y, Hofe Fv, Zentner J, Jacobs J, Klotz KA (2025)
Publication Type: Journal article, Review article
Publication year: 2025
Journal
Book Volume: 2025
Article Number: 3453458
Journal Issue: 1
DOI: 10.1155/ane/3453458
Abstract
Hemispherectomy is the most promising treatment for patients with severe hemispheric intractable epilepsy. Several techniques for this surgical intervention have been established, but the choice of technique is currently mostly dependent on the surgeon’s experience with a specific approach. We aim to demonstrate whether the choice of the surgical technique moderates surgical outcome in patients with severe hemispheric intractable epilepsy, as measured by seizure freedom and the incidence of death after surgery. We extracted 2382 articles from PubMed and Cochrane. Two independent experts selected 555 articles. We performed a meta-analysis for all studies and a pooled data analysis for studies where information on individual patients was available. None of the retrieved studies was randomized. Disconnective surgery yielded significantly higher rates of seizure freedom (0.83) than resective (0.70, p < 0.001) or combined surgery (0.64, p < 0.001) for patients with at least 1 year follow–up (N cases = 1165). For death (N cases = 1197), resective surgery had the highest rate of death within a year (0.07), significantly higher than disconnective surgery (0.012, p = 0.001) and combined surgical techniques (0.006, p < 0.001). The assessed techniques did not systematically differ in rate of acute complications, but in their type, for example, acute neurological complications were most common after disconnective surgery (p < 0.001), unspecific symptoms after resective surgery (p < 0.004). Chronic neurological complications were most common after resective surgery (p < 0.001). Seizure freedom is more likely following disconnective surgery as compared to resective or combined techniques. Disconnective and combined surgical techniques lead to fewer chronic complications and death than resective approaches.
Involved external institutions
Universitätsklinikum Freiburg
Germany (DE)
University of Akureyri / Háskólinn á Akureyri
Iceland (IS)
University of Calgary
Canada (CA)
Germany (DE)
University of Akureyri / Háskólinn á Akureyri
Iceland (IS)
University of Calgary
Canada (CA)
How to cite
APA:
Puhahn-Schmeiser, B., Höller, Y., Hofe, F.v., Zentner, J., Jacobs, J., & Klotz, K.A. (2025). Disconnective Approach Leads to Superior Seizure Outcome Compared to Other Hemispheric Procedures—A Meta-Analysis. Acta Neurologica Scandinavica, 2025(1). https://doi.org/10.1155/ane/3453458
MLA:
Puhahn-Schmeiser, Barbara, et al. "Disconnective Approach Leads to Superior Seizure Outcome Compared to Other Hemispheric Procedures—A Meta-Analysis." Acta Neurologica Scandinavica 2025.1 (2025).
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