Comparison of twelve-layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI

Gallinnis PJ, Möller R, Ljimani A, Cabuk Y, Scheuer M, Böttger C, Liang C, Nagel AM, Bechler E, Wittsack HJ, Müller-Lutz A, Kamp B (2025)

Publication Language: English

Publication Type: Journal article

Publication year: 2025

Journal

Magnetic Resonance in Medicine Wiley

Book Volume: 94

Pages Range: 1318-1325

Journal Issue: 3

DOI: 10.1002/mrm.30525

Abstract

Purpose: 23Na MRI is a functional imaging technique that facilitates measurements of the renal corticomedullary sodium gradient (CMSG). The CMSG can be determined by a region of interest (ROI) in the renal parenchyma along the corticomedullary axis (Line method) or by dividing the renal parenchyma into concentric layers, using the twelve-layer concentric objects (TLCO) method. The aim of this study was to investigate the differences, strengths, and weaknesses in determining the CMSG using these methods. Methods: Ten healthy volunteers were examined on a 3 T MRI-system. 23Na images were acquired using a double-tuned 23Na/1H surface coil and a golden angle (GA) density-adapted 3D radial (DA-3D-RAD) sequence. The CMSG was determined with the Line and TLCO methods. Intra- and inter-reader analyses were performed by two radiologists. Results: The evaluated CMSG by the two methods does not differ statistically significantly. Compared to the Line method, the TLCO method provides improved results in terms of reliability, precision, reproducibility, and concordance in intra- and inter-reader analyses. A CMSG of (6.7 ± 2.6) mM/mm was determined using the TLCO method in the segmentation process with the lowest standard deviation. Conclusion: The TLCO method shows superior performance in determining the CMSG compared to the Line method. Accordingly, the use of the TLCO method is recommended for future renal CMSG studies.

Authors with CRIS profile

Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung

Involved external institutions

Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsklinikum Tübingen DE Germany (DE)

How to cite

APA:

Gallinnis, P.J., Möller, R., Ljimani, A., Cabuk, Y., Scheuer, M., Böttger, C.,... Kamp, B. (2025). Comparison of twelve-layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI. Magnetic Resonance in Medicine, 94(3), 1318-1325. https://doi.org/10.1002/mrm.30525

MLA:

Gallinnis, Patrik Jan, et al. "Comparison of twelve-layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI." Magnetic Resonance in Medicine 94.3 (2025): 1318-1325.

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