Axially vascularized bone substitutes: A systematic review of literature and presentation of a novel model

Eweida AM, Nabawi AS, Elhammady HA, Marei MK, Khalil MR, Shawky MS, Arkudas A, Beier J, Unglaub F, Kneser U, Horch RE (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Archives of Orthopaedic and Trauma Surgery Springer Verlag (Germany)

Book Volume: 132

Pages Range: 1353-1362

Journal Issue: 9

DOI: 10.1007/s00402-012-1550-3

Abstract

Introduction The creation of axially vascularized bone substitutes (AVBS) has been successfully demonstrated in several animal models. One prototypical indication is bone replacement in patients with previously irradiated defect sites, such as in the mandibular region. The downside of current clinical practice, when free fibular or scapular grafts are used, is the creation of significant donor site morbidity. Methods Based on our previous experiments, we extended the creation of an arterio-venous loop to generate vascularized bone substitutes to a new defect model in the goat mandibula. In this report, we review the literature regarding different models for axially vascularized bone substitutes and present a novel model demonstrating the feasibility of combining this model with synthetic porous scaffold materials and biological tissue adhesives to grow cells and tissue. Results We were able to show the principal possibility to generate axially vascularized bony substitutes in vivo in goat mandibular defects harnessing the regenerative capacity of the living organism and completely avoiding donor site morbidity. Conclusion From our findings, we conclude that this novel model may well offer new perspectives for orthopedic and traumatic bone defects that might benefit from the reduction of donor site morbidity. © Springer-Verlag 2012;.

Authors with CRIS profile

Andreas Arkudas Medizinische Fakultät Raymund Horch Professur für Plastische Chirurgie und Handchirurgie

Involved external institutions

Vulpius Klinik DE Germany (DE)

How to cite

APA:

Eweida, A.M., Nabawi, A.S., Elhammady, H.A., Marei, M.K., Khalil, M.R., Shawky, M.S.,... Horch, R.E. (2012). Axially vascularized bone substitutes: A systematic review of literature and presentation of a novel model. Archives of Orthopaedic and Trauma Surgery, 132(9), 1353-1362. https://doi.org/10.1007/s00402-012-1550-3

MLA:

Eweida, A. M., et al. "Axially vascularized bone substitutes: A systematic review of literature and presentation of a novel model." Archives of Orthopaedic and Trauma Surgery 132.9 (2012): 1353-1362.

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