Therapy of early breast cancer: current status and perspectives

Tauber N, Amann N, Dannehl D, Deutsch TM, Dimpfl M, Fasching P, Hartkopf A, Heublein S, Hilmer L, Hörner M, Krawczyk N, Krückel A, Krug D, Marmé F, Michel LL, Reinisch M, Rody A, Schäffler H, Schneeweiss A, Utz D, Veselinovic K, Banys-Paluchowski M (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

Archives of Gynecology and Obstetrics Springer

DOI: 10.1007/s00404-025-08028-0

Abstract

Medical advancements in breast cancer are truly remarkable. Especially in recent years, numerous new therapeutics have been approved and surgical strategies have been de-escalated for specific patient groups. In the therapeutic setting, CDK4/6 inhibitors as oral maintenance therapy in early breast cancer and immune checkpoint inhibitors (Pembrolizumab) for triple-negative breast cancer (BC) are noteworthy. In the surgical field, prospective randomized controlled trials have currently explored the possibility to deescalate axillary surgery by omitting sentinel lymph node excision (INSEMA, SOUND). As a result, there have been significant improvements in prognosis and a reduction in surgical morbidity for patients. Many exciting trials are underway, and it remains to be seen whether antibody–drug conjugates beyond trastuzumab emtansine, will find their way into the treatment lines for early-stage BC. Furthermore, the integration of artificial intelligence in both diagnostics and treatment recommendation evaluation is a promising area with great potential.

Authors with CRIS profile

Niklas Amann Department of Obstetrics and Gynaecology Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Manuel Hörner Department of Obstetrics and Gynaecology Annika Krückel Department of Obstetrics and Gynaecology

Involved external institutions

Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Universitätsklinikum Tübingen DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE)

How to cite

APA:

Tauber, N., Amann, N., Dannehl, D., Deutsch, T.M., Dimpfl, M., Fasching, P.,... Banys-Paluchowski, M. (2025). Therapy of early breast cancer: current status and perspectives. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-025-08028-0

MLA:

Tauber, Nikolas, et al. "Therapy of early breast cancer: current status and perspectives." Archives of Gynecology and Obstetrics (2025).

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