Fluid-Suppressed Amide Proton Transfer-Weighted Imaging Outperforms Leakage-Corrected Dynamic Susceptibility Contrast Perfusion in Distinguishing Progression from Radionecrosis in Brain Metastases

Nichelli L, Casagranda S, Dipasquale O, Bensemain M, Papageorgakis C, Zucchelli M, Jacob J, Valery C, Mathon B, Liebig P, Zaiß M, Lehéricy S (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Cancers MDPI

Book Volume: 17

Article Number: 1175

Journal Issue: 7

DOI: 10.3390/cancers17071175

Abstract

Assessing a response in an evolving irradiated brain metastasis is difficult and at the same time pivotal for patient care, as it can reflect radionecrosis or tumor progression, two entities with antithetical clinical management. At present, DSC perfusion after leakage correction is the reference MRI technique in this evaluation. Our preliminary study demonstrated that fluid-suppressed APTw better discriminated radionecrosis from tumor progression in comparison to leakage-corrected rCBV imaging. These findings contribute to the expanding body of evidence supporting the added value of APTw imaging in neuro-oncology. However, while there is robust evidence of the potential of APTw in gliomas, studies that include APTw imaging in metastases are scarce, and no study has evaluated a fluid artifact correction approach in APTw maps in therapeutic assessments of brain metastases. This study suggests that fluid-suppressed APTw could serve as a valuable addition to multimodal imaging protocols in post-treatment tumor assessments.

Authors with CRIS profile

Moritz Zaiß Professur für Multimodale Bildgebung in der klinischen Forschung

Involved external institutions

Sorbonne Université FR France (FR) Olea Medical - Improved Diagnosis for Life FR France (FR) Assistance Publique-Hôpitaux de Paris (AP-HP) FR France (FR)

How to cite

APA:

Nichelli, L., Casagranda, S., Dipasquale, O., Bensemain, M., Papageorgakis, C., Zucchelli, M.,... Lehéricy, S. (2025). Fluid-Suppressed Amide Proton Transfer-Weighted Imaging Outperforms Leakage-Corrected Dynamic Susceptibility Contrast Perfusion in Distinguishing Progression from Radionecrosis in Brain Metastases. Cancers, 17(7). https://doi.org/10.3390/cancers17071175

MLA:

Nichelli, Lucia, et al. "Fluid-Suppressed Amide Proton Transfer-Weighted Imaging Outperforms Leakage-Corrected Dynamic Susceptibility Contrast Perfusion in Distinguishing Progression from Radionecrosis in Brain Metastases." Cancers 17.7 (2025).

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