Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites
Schütz B, Krause FF, Taudte RV, Zaiss M, Luu M, Visekruna A (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 55
Article Number: e202451594
Journal Issue: 4
Abstract
In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal microorganisms and the host immune system. Research on the human microbiome is evolving from merely descriptive and correlative studies to a deeper mechanistic understanding of the bidirectional interactions between gut microbiota and the mucosal immune system. Despite numerous challenges, it has become increasingly evident that an imbalance in gut microbiota composition, known as dysbiosis, is associated with the development and progression of various metabolic, immune, cancer, and neurodegenerative disorders. A growing body of evidence highlights the importance of small molecules produced by intestinal commensal bacteria, collectively referred to as gut microbial metabolites. These metabolites serve as crucial diffusible messengers, translating the microbial language to host cells. This review aims to explore the complex and not yet fully understood molecular mechanisms through which microbiota-derived metabolites influence the activity of the immune cells and shape immune reactions in the gut and other organs. Specifically, we will discuss recent research that reveals the close relationship between microbial indole-3-propionic acid (IPA) and mucosal immunity. Furthermore, we will emphasize the beneficial effects of IPA on intestinal inflammation and discuss its potential clinical implications.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Schütz, B., Krause, F.F., Taudte, R.V., Zaiss, M., Luu, M., & Visekruna, A. (2025). Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites. European Journal of Immunology, 55(4). https://doi.org/10.1002/eji.202451594
MLA:
Schütz, Burkhard, et al. "Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites." European Journal of Immunology 55.4 (2025).
BibTeX: Download