Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey.

Yoshida A, Li Y, Maroufy V, Kuwana M, Shaharir SS, Makol A, Sen P, Lilleker JB, Agarwal V, Kadam E, Goo PA, Day J, Milchert M, Chen YM, Dey D, Velikova T, Saha S, Gracia-Ramos AE, Parodis I, Nikiphorou E, Tan AL, Nune A, Cavagna L, Gutiérrez CET, Caballero-Uribe CV, Saavedra MA, Shinjo SK, Ziade N, Kibbi LE, Knitza J, Chinoy H, Distler O, Agarwal V, Aggarwal R, Gupta L (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 8

Journal Issue: 2

DOI: 10.1093/rap/rkae028

Abstract

OBJECTIVES: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database. METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis. RESULTS: We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs vs 13 [11-15] non-IIM AIRDs vs 15 [13-17] nrAIDs vs 17 [15-18] controls, P < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10-15) IIMs vs 15 (13-17) controls, P < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients. CONCLUSION: Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.

Authors with CRIS profile

Involved external institutions

University of Texas Health Science Center at Houston (UTHealth) United States (USA) (US) University Kebangsaan Malaysia Medical Centre / Pusat Perubatan Universiti Kebangsaan Malaysia Malaysia (MY) Mayo Clinic United States (USA) (US) Maulana Azad Medical College (MAMC) India (IN) University of Manchester United Kingdom (GB) Mahatma Gandhi Mission Medical College and Hospital India (IN) King Edward Memorial Hospital and Seth G.S. Medical College / கிங் எட்வர்ட் நினைவு மருத்துவமனை,राजा एड्वर्ड स्मारक रुग्णालय व सेठ गोवर्धनदास सुंदरदास वैद्यकीय महाविद्यालय India (IN) Queen Savang Vadhana Memorial Hospital / โรงพยาบาลสมเด็จพระบรมราชเทวี ณ ศรีราชา Thailand (TH) Royal Melbourne Hospital (RMH) Australia (AU) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Taichung Veterans General Hospital Taiwan (TW) University of Ghana Ghana (GH) Sofia University "St. Kliment Ohridski" / Софийски университет "Св. Климент Охридски" Bulgaria (BG) Mymensingh Medical College / ময়মনসিংহ মেডিকেল কলেজ Bangladesh (BD) Instituto Mexicano del Seguro Social Mexico (MX) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) King’s College London United Kingdom (GB) NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU) United Kingdom (GB) Southport and Ormskirk Hospital NHS Trust United Kingdom (GB) Università degli Studi di Pavia Italy (IT) Pontifical Xavierian University / Pontificia Universidad Javeriana Colombia (CO) Universidad del Norte Colombia (CO) Centro Medico Nacional Siglo XXI Mexico (MX) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB) Alfaisal University Saudi Arabia (SA) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) University of Pittsburgh United States (USA) (US)

How to cite

APA:

Yoshida, A., Li, Y., Maroufy, V., Kuwana, M., Shaharir, S.S., Makol, A.,... Gupta, L. (2024). Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey. Rheumatology Advances in Practice, 8(2). https://doi.org/10.1093/rap/rkae028

MLA:

Yoshida, Akira, et al. "Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey." Rheumatology Advances in Practice 8.2 (2024).

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