Defining a bad barrett's segment: Is it dependent on goblet cells
Vieth M, Barr H (2009)
Publication Type: Journal article, Review article
Publication year: 2009
Journal
Book Volume: 104
Pages Range: 825-827
Journal Issue: 4
DOI: 10.1038/ajg.2009.90
Abstract
The identification of patients with bad Barrett's who are at risk of neoplastic progression is a vital and pressing task. The view that specialized intestinal metaplasia with goblet cells is the predominant preneoplastic phenotype has had wide, but by no means universal, acceptance. An important caveat is presented in the thoughtful paper by Liu et al. in this issue. Of 68 patients with columnar metaplasia, 22 patients had no goblet cells identified and 46 had goblet cells in their biopsies. In both groups there were chromosomal and DNA content abnormalities and genetic instability. However, there were no significant differences between these cellular DNA abnormalities in the two groups. Both were significantly different from gastric controls. Thus, all metaplasia in the columnar-lined esophagus may already be on the path to cancer. © 2009 by the American College of Gastroenterology.
Involved external institutions
Germany (DE)How to cite
APA:
Vieth, M., & Barr, H. (2009). Defining a bad barrett's segment: Is it dependent on goblet cells. American Journal of Gastroenterology, 104(4), 825-827. https://doi.org/10.1038/ajg.2009.90
MLA:
Vieth, M., and H. Barr. "Defining a bad barrett's segment: Is it dependent on goblet cells." American Journal of Gastroenterology 104.4 (2009): 825-827.
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