Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: A matched-pairs study
Peitz U, Wex T, Vieth M, Stolte M, Willich S, Labenz J, Jaspersen D, Lind T, Malfertheiner P (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 26
Pages Range: 82-89
Journal Issue: 1
DOI: 10.1111/j.1440-1746.2010.06413.x
Abstract
Background and Aim: An algorithm (GastroPanel) for the non-invasive diagnosis of atrophic gastritis has been previously proposed, based on serum pepsinogen-I, gastrin-17, and Helicobacter pylori (H. pylori) antibodies. The aim of the present study was to evaluate whether serum markers correlate with and predict gastric atrophy in gastroesophageal reflux disease (GERD) patients.Methods: The baseline data of the prospective ProGERD study, a study on the long-term course of GERD (n = 6215 patients), served to select patients with atrophic gastritis diagnosed in biopsies from gastric antrum and corpus, and control cases without atrophy. A total of 208 pairs were matched for age, sex, GERD status (erosive vs non-erosive), presence of Barrett's esophagus, and histological H. pylori status were retrieved. Serum pepsinogen-I, gastrin-17, and H. pylori antibodies were determined using specific enzyme immunoassays.Results: A significant negative correlation was found between the degree of corpus atrophy and the level of serum pepsinogen-I. A previously-reported negative correlation between the degree of antral atrophy and serum gastrin-17 could not be confirmed. The low sensitivity (0.32) and specificity (0.70) of the GastroPanel algorithm were mainly due to over diagnosis and under diagnosis of advanced atrophy in the antrum.Conclusion: The diagnostic validity of the GastroPanel algorithm to diagnose gastric atrophy non-invasively is not sufficient for general use in GERD patients. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Involved external institutions
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Klinikum Bayreuth
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Diakonie Klinikum Jung-Stilling
Germany (DE)
Klinikum Fulda
Germany (DE)
AstraZeneca Sweden
Sweden (SE)
Germany (DE)
Klinikum Bayreuth
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Diakonie Klinikum Jung-Stilling
Germany (DE)
Klinikum Fulda
Germany (DE)
AstraZeneca Sweden
Sweden (SE)
How to cite
APA:
Peitz, U., Wex, T., Vieth, M., Stolte, M., Willich, S., Labenz, J.,... Malfertheiner, P. (2011). Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: A matched-pairs study. Journal of Gastroenterology and Hepatology, 26(1), 82-89. https://doi.org/10.1111/j.1440-1746.2010.06413.x
MLA:
Peitz, Ulrich, et al. "Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: A matched-pairs study." Journal of Gastroenterology and Hepatology 26.1 (2011): 82-89.
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