Is the Routine Histopathologic Diagnosis of Ulcerative Colitis Based on Cross-cut Sections or on Well-oriented Sections?

Rubio CA, Lang-Schwarz C, Vieth M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Cancer Diagnosis & Prognosis International Institute of Anticancer Research

Book Volume: 3

Pages Range: 334-337

Journal Issue: 3

DOI: 10.21873/cdp.10220

Abstract

Background/Aim: For many years, it was empirically estimated that the majority of the routine colon biopsies in Swedish patients with ulcerative colitis (UC), exhibited cross-cut crypts. The aim of the present study was to assess the frequency of cross-cut crypts (CCC) and well-oriented crypts in routine colon biopsies in German patients with UC. Patients and Methods: In total, 447 colon biopsies: 376 with UC and 71 controls were investigated. Results: Out of 376 colon biopsies with UC, 73% exhibited ≥60% CCC. Out of the 237 biopsies showing ≥80% CCC, as many as 71% exhibited 100% CCC in individual biopsies. Similar percentages were found in control biopsies. Conclusion: The majority of the routine colon biopsies with UC, as well as control biopsies in German patients displayed CCC. Thus, an unnoticed, consequent, and systematic cutting technical hitch was introduced during the laboratory processing of colon biopsies. The reason(s) behind the similar histologic processing mode of colon biopsies at the two geographically disparate laboratories (Sweden and Germany) remains elusive. The cross-cutting mode influenced the narrative of biopsies in UC, inasmuch as some histological parameters listed among well-oriented colon sections were not present in sections displaying CCC.

Authors with CRIS profile

Corinna Lang-Schwarz Institute of Pathology Michael Vieth Professur für Allgemeine Pathologie am Medizincampus Oberfranken

Involved external institutions

Karolinska Institute SE Sweden (SE)

How to cite

APA:

Rubio, C.A., Lang-Schwarz, C., & Vieth, M. (2023). Is the Routine Histopathologic Diagnosis of Ulcerative Colitis Based on Cross-cut Sections or on Well-oriented Sections? Cancer Diagnosis & Prognosis, 3(3), 334-337. https://doi.org/10.21873/cdp.10220

MLA:

Rubio, Carlos A., Corinna Lang-Schwarz, and Michael Vieth. "Is the Routine Histopathologic Diagnosis of Ulcerative Colitis Based on Cross-cut Sections or on Well-oriented Sections?" Cancer Diagnosis & Prognosis 3.3 (2023): 334-337.

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