IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells
Yang B, Piedfort O, Sanchez-Sanchez G, Lavergne A, Gong M, Peng G, Madrigal A, Petrellis G, Katsandegwaza B, Rodriguez LR, Balthazar A, Meyer SJ, Van Isterdael G, Van Duyse J, Andris F, Bai Q, Marichal T, Machiels B, Nitschke L, Najafabadi HS, King IL, Vermijlen D, Dewals BG (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 10
Pages Range: eadk4841-
Journal Issue: 104
DOI: 10.1126/sciimmunol.adk4841
Abstract
Parasitic helminths induce the production of interleukin-4 (IL-4), which causes the expansion of virtual memory CD8+ T cells (TVM cells), a cell subset that contributes to the control of coinfection with intracellular pathogens. However, the mechanisms regulating IL-4-dependent TVM cell activation and expansion remain ill defined. Here, we used single-cell RNA sequencing of CD8+ T cells to identify pathways that control IL-4-dependent TVM cell responses. Gene signature analysis of CD8+ T cells identified a cell cluster marked by CD22, a canonical regulator of B cell activation, as a selective surface marker of IL-4-induced TVM cells. CD22+ TVM cells were enriched for interferon-γ and granzyme A and retained a diverse TCR repertoire while enriched in self-reactive CDR3 sequences. CD22 intrinsically regulated the IL-4-induced CD8+ T cell effector program, resulting in reduced responsiveness of CD22+ TVM cells and regulatory functions to infection and inflammation. Thus, helminth-induced IL-4 drives the expansion and activation of TVM cells that is counterinhibited by CD22.
Authors with CRIS profile
Involved external institutions
McGill University
Canada (CA)
McGill University Health Centre (MUHC) / Centre universitaire de santé McGill
Canada (CA)
Université libre de Bruxelles (ULB) / Free University of Brussels
Belgium (BE)
University of Liège (ULg) / Université de Liège
Belgium (BE)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Belgium (BE)
Canada (CA)
McGill University Health Centre (MUHC) / Centre universitaire de santé McGill
Canada (CA)
Université libre de Bruxelles (ULB) / Free University of Brussels
Belgium (BE)
University of Liège (ULg) / Université de Liège
Belgium (BE)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Belgium (BE)
How to cite
APA:
Yang, B., Piedfort, O., Sanchez-Sanchez, G., Lavergne, A., Gong, M., Peng, G.,... Dewals, B.G. (2025). IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells. Science immunology, 10(104), eadk4841-. https://doi.org/10.1126/sciimmunol.adk4841
MLA:
Yang, Bin, et al. "IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells." Science immunology 10.104 (2025): eadk4841-.
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