Exploring the causal relationship between GLP-1R agonists and diseases related to the thyroid and parathyroid: a mendelian randomization study

Li C, Shen K, Pan L (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Journal of Diabetes & Metabolic Disorders Tehran University of Medical Sciences / BioMed Central

Book Volume: 24

Article Number: 64

Journal Issue: 1

DOI: 10.1007/s40200-025-01567-y

Abstract

Glucagon-like peptide-1 receptor (GLP-1R) agonists are well-known for their benefits in managing obesity and diabetes. However, some studies indicate that they may elevate the risk of thyroid cancer. This study employed summary data-based Mendelian randomization (SMR) analysis, incorporating genetic data from GTEx V.8 and the UK Biobank, to assess how increased GLP-1R gene expression in thyroid and parathyroid tissues affects their functions. We found that increased expression of GLP-1R is a risk factor for hyperparathyroidism, but no causal relationship was found with thyroid dysfunction. Furthermore, we advise routine assessments of parathyroid function and hormone levels for patients on GLP-1R agonists.

Authors with CRIS profile

Caihong Li Institute of Clinical and Molecular Virology

Involved external institutions

Peking Union Medical College Hospital (PUMCH) / Beijing Xiehe Hospital CN China (CN) Klinikum rechts der Isar DE Germany (DE)

How to cite

APA:

Li, C., Shen, K., & Pan, L. (2025). Exploring the causal relationship between GLP-1R agonists and diseases related to the thyroid and parathyroid: a mendelian randomization study. Journal of Diabetes & Metabolic Disorders, 24(1). https://doi.org/10.1007/s40200-025-01567-y

MLA:

Li, Caihong, Keyu Shen, and Lingfeng Pan. "Exploring the causal relationship between GLP-1R agonists and diseases related to the thyroid and parathyroid: a mendelian randomization study." Journal of Diabetes & Metabolic Disorders 24.1 (2025).

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