The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies

Auer S, Schicht M, Hoffmann L, Budday S, Frischknecht R, Blümcke I, Paulsen F (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Cells MDPI

Book Volume: 14

Pages Range: 321

Issue: 5

DOI: 10.3390/cells14050321

Abstract

Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability. This literature review aims to summarize the current state of knowledge about PNNs, their molecular composition and structure, as well as their functional roles and involvement in neurological diseases. Furthermore, future directions in PNN research are proposed, and the therapeutic potential of targeting PNNs to develop novel treatment options for various neurological disorders is explored. This review emphasizes the importance of PNNs in CNS physiology and pathology and underscores the need for further research in this area.

Authors with CRIS profile

Sophia Auer Lehrstuhl für Funktionelle und Klinische Anatomie Martin Schicht Lehrstuhl für Funktionelle und Klinische Anatomie Lucas Hoffmann Institute of Neuropathology Silvia Budday Lehrstuhl für Kontinuumsmechanik (Schwerpunkt Biomechanik) Renato Frischknecht Lehrstuhl für Tierphysiologie Ingmar Blümcke Lehrstuhl für Neuropathologie Friedrich Paulsen Lehrstuhl für Funktionelle und Klinische Anatomie

Additional Organisation(s)

Sonderforschungsbereich 1540/1 - Erforschung der Mechanik des Gehirns (EBM): Verständnis, Engineering und Nutzung mechanischer Eigenschaften und Signale in der Entwicklung, Physiologie und Pathologie des zentralen Nervensystems

How to cite

APA:

Auer, S., Schicht, M., Hoffmann, L., Budday, S., Frischknecht, R., Blümcke, I., & Paulsen, F. (2025). The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies. Cells, 14, 321. https://doi.org/10.3390/cells14050321

MLA:

Auer, Sophia, et al. "The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies." Cells 14 (2025): 321.

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