Constable P, Pinzon-Arenas JO, Mercado Diaz LR, Lee I, Marmolejo-Ramos F, Loh L, Zhdanov A, Kulyabin M, Brabec M, Skuse D, Thompson DA, Posada-Quintero HF (2025)
Publication Language: English
Publication Type: Journal article, Original article
Publication year: 2025
Book Volume: 12
Pages Range: 15
Article Number: 15
Journal Issue: 1
DOI: 10.3390/bioengineering12010015
Open Access Link: https://www.mdpi.com/2306-5354/12/1/15
Electroretinograms (ERGs) show differences between typically developing populations and those with a diagnosis of autism spectrum disorder (ASD) or attention deficit/hyperactivity disorder (ADHD). In a series of ERGs collected in ASD (n = 77), ADHD (n = 43), ASD + ADHD (n = 21), and control (n = 137) groups, this analysis explores the use of machine learning and feature selection techniques to improve the classification between these clinically defined groups. Standard time domain and signal analysis features were evaluated in different machine learning models. For ASD classification, a balanced accuracy (BA) of 0.87 was achieved for male participants. For ADHD, a BA of 0.84 was achieved for female participants. When a three-group model (ASD, ADHD, and control) the BA was lower, at 0.70, and fell further to 0.53 when all groups were included (ASD, ADHD, ASD + ADHD, and control). The findings support a role for the ERG in establishing a broad two-group classification of ASD or ADHD, but the model’s performance depends upon sex and is limited when multiple classes are included in machine learning modeling.
APA:
Constable, P., Pinzon-Arenas, J.O., Mercado Diaz, L.R., Lee, I., Marmolejo-Ramos, F., Loh, L.,... Posada-Quintero, H.F. (2024). Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning. Bioengineering, 12(1), 15. https://doi.org/10.3390/bioengineering12010015
MLA:
Constable, Paul, et al. "Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning." Bioengineering 12.1 (2024): 15.
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