Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Investigators

Voll F, Olivecronab G, Ferenc M, Hellig F, Schlundt C, Wöhrle J, Cassese S, Rottbauer W, Witkowski A, Xhepa E, Kuliczkowski W, Strauss L, Schrage B, Joner M, von zur Mühlen C, Cook S, Miljak T, Eggebrecht H, Eeckhout E, Laugwitz KL, Monsegu J, Schunkert H, Westermann D, Kastrati A, Dumonteil N, Birkemeyer R, Kufner S (2025)

Publication Type: Journal article

Publication year: 2025

Journal

DOI: 10.1007/s12928-025-01084-y

Abstract

New-generation single-layer polytetrafluorethylene (PTFE-) or polyurethane (PU-) covered stent (CS) for the treatment of coronary artery perforation (CAP) during PCI offer high procedural efficacy. To evaluate the comparative long-term safety and efficacy of both devices. This is a multicenter pooled analysis of individual data of patients with CAP undergoing implantation of single-layer PTFE-CS or PU-CS. Procedural endpoint was strategy success defined as successful placement of CS and sealing of perforation without surgical conversion. Clinical endpoints were mortality, myocardial infarction (MI), target vessel revascularization (TVR) and definite or probable stent thrombosis (def/prob ST) at 12 months. Seventy patients with CAP underwent implantation of two hundred eight CS, ninety-two PTFE-CS, and one hundred sixteen PU-CS. More than 1 stent was implanted in 13 patients (17.1%) in PTFE-CS group and 19 patients (20.2%) in PU-CS group, P = 0.80. Strategy success was high (96.1% versus 92.5%., P = 0.62). At 12 months, 71 patients (93.2%) in PTFE-CS group versus 79 patients (81%) in the PU-CS were alive, P = 0.05; TVR occurred in 14 patients (28.4%) in PTFE-CS group and 12 patients (17.9%) in PU-CS group, P= 0.54; MI in 1 patient (1.3%) in PTFE-CS group and 1 patients (1.1%) in PU-CS group, P = 0.86. Rates of def/prob ST were comparable 1.3% in PTFE-CS versus 3.1% in PU-CS P = 0.95. A strategy of implantation of a new-generation single-layer PTFE- or PU-CS for the treatment of coronary artery perforation showed high success rates. Both new-generation CS showed favorable and similar clinical safety, in particular with regard to thrombotic events.

Authors with CRIS profile

Involved external institutions

Technische Universität München (TUM) Germany (DE) Lund University / Lunds universitet Sweden (SE) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu Poland (PL) Netcare Sunninghill Hospital South Africa (ZA) Medizin Campus Bodensee Germany (DE) Cardioangiologische Centrum Bethanien Germany (DE) Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV) Switzerland (CH) Universität Ulm Germany (DE) Klinikum rechts der Isar Germany (DE) Clinique Pasteur France (FR) Herzklinik Ulm Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Klinikverbund Südwest (Sindelfingen-Böblingen, Calw, Nagold, Leonberg, Herrenberg) Germany (DE) Groupe Hospitalier Mutualiste de Grenoble / Mutual Hospital Group of Grenoble France (FR) Institute of Cardiology in Warsaw Poland (PL) Universitäts-Herzzentrum Freiburg - Bad Krozingen GmbH Germany (DE) freiburger spitals (HFR) / hôpital fribourgeois Switzerland (CH)

How to cite

APA:

Voll, F., Olivecronab, G., Ferenc, M., Hellig, F., Schlundt, C., Wöhrle, J.,... Kufner, S. (2025). Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Investigators. Cardiovascular Intervention and Therapeutics. https://doi.org/10.1007/s12928-025-01084-y

MLA:

Voll, Felix, et al. "Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Investigators." Cardiovascular Intervention and Therapeutics (2025).

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