Pfister H (2024)
Publication Type: Authored book
Publication year: 2024
Publisher: CRC Press
ISBN: 9781040293706
Papillomavirus infections can usually be diagnosed by the clinician based on the morphology and histology of human papillomavirus (HPV)-induced tumors, which are described extensively in Chapters 2 to 4 of this volume. The diagnosis of genital HPV infections occupies a special position. The induced lesions are regarded as precursors of anogenital cancer and a screening for not yet obvious, early symptoms therefore plays an important role for preventive medical check-up. This is, so far, almost invariably based on the cytologic detection of koilocytes and dyskeratotic cells (see Chapter 2). The colposcope may aid diagnosis or be necessary in cases of subclinical lesions. The application of 5% acetic acid leads to an “acetowhite” epithelium and to the visualization of pathological vessels, which are both characteristic of HPV infection. Colposcopy is particularly useful to examine the external skin of the vulva, penis, and scrotum, where smears do not provide enough cells from deeper epithelial layers for cytologic evaluation.1 Even for examination of the cervix uteri, colposcopy proved to be more sensitive than cytology in detecting borderline HPV-associated lesions, showing only a lack of glycogenation, acanthosis, and elongation of rete pegs.2
APA:
Pfister, H. (2024). DETECTION OF HUMAN PAPILLOMAVIRUS INFECTION AND PROSPECTS FOR DIAGNOSTICS. CRC Press.
MLA:
Pfister, Herbert. DETECTION OF HUMAN PAPILLOMAVIRUS INFECTION AND PROSPECTS FOR DIAGNOSTICS. CRC Press, 2024.
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