Adverse drug events related to COX inhibitors in patients presenting at an emergency department: Cross-sectional study of prevalence and risk factors

Pfistermeister B, Dormann H, Patapovas A, Müller F, Sonst A, Gläser H, Plank-Kiegele B, Bürkle T, Maas R (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Notfall und Rettungsmedizin Springer Verlag (Germany)

Book Volume: 19

Pages Range: 671-678

Journal Issue: 8

DOI: 10.1007/s10049-016-0184-3

Abstract

Background: The use of cyclooxygenase (COX) inhibitors is increasingly common. Most of them are available for self-medication, either as analgesic or for cardio- and cerebrovascular prevention. Objectives: We aimed to analyze adverse drug events (ADE) related to COX inhibitors and the concomitant use of proton pump inhibitors (PPI) according to guidelines in patients presenting at an emergency department (ED). Methods: In a prospective study, 2262 patients presenting consecutively at the ED of a tertiary care university teaching hospital were evaluated by intensive chart review in order to detect and classify all ADE. In this cross-sectional analysis all patients taking COX inhibitors at home were evaluated further. Results: Of all evaluated patients, 753 (33.3 %) took COX inhibitors at home, 258 (34.3 %) with concomitant PPI. A total of 168 (22.3 %) patients suffered from at least one ADE related to COX inhibitors. The most common ADE observed were anemia (55.9 %) and gastrointestinal ADE (31.6 %, e. g., bleeding, gastritis, and ulcer). In 10.1 % of patients, a medication error (e. g., intake without proper clinical indication) contributed to the ADE and in 40.8 % of the ADE involved further contributing drugs. Only 38.8–42.1 % of patients with a high gastrointestinal risk were prescribed a PPI concomitantly. Conclusion: ADE related to COX inhibitors were found in every fifth patient taking COX inhibitors. One-tenth of all ADE involving COX inhibitors were related to medication errors. The guideline-based concomitant use of PPI was only in part implemented.

Authors with CRIS profile

Barbara Pfistermeister Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Andrius Patapovas Lehrstuhl für Medizinische Informatik Fabian Müller Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Hartmut Gläser Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Bettina Plank-Kiegele Institut für Experimentelle und Klinische Pharmakologie und Toxikologie Renke Maas Professur für Arzneimitteltherapiesicherheit und Klinische Pharmakologie

Involved external institutions

Berner Fachhochschule (BFH) CH Switzerland (CH) Klinikum Fürth DE Germany (DE)

How to cite

APA:

Pfistermeister, B., Dormann, H., Patapovas, A., Müller, F., Sonst, A., Gläser, H.,... Maas, R. (2016). Adverse drug events related to COX inhibitors in patients presenting at an emergency department: Cross-sectional study of prevalence and risk factors. Notfall und Rettungsmedizin, 19(8), 671-678. https://doi.org/10.1007/s10049-016-0184-3

MLA:

Pfistermeister, Barbara, et al. "Adverse drug events related to COX inhibitors in patients presenting at an emergency department: Cross-sectional study of prevalence and risk factors." Notfall und Rettungsmedizin 19.8 (2016): 671-678.

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