Intraoperative optical biopsy assessment during TORS head and neck cancer resections-a novel application of confocal laser endomicroscopy with intravenous fluorescein

Jeyarajan H, Chaudhary I, Fuson A, James S, Wodeyar A, Sievert M, Goncalves M, Thomas CM, Warram J, Panuganti BA (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Oral Oncology Reports Elsevier

Book Volume: 13

Article Number: 100702

DOI: 10.1016/j.oor.2024.100702

Abstract

Margin assessment during transoral robotic surgical (TORS) resections of head and neck mucosal malignancies can be complex, originating in part from discrepancies in definitions of positive or close margins, and the technical difficulty of revising microscopic margins intraoperatively without incurring the functional consequences associated with soft tissue deficits in the oropharynx and larynx. Intraoperative optical imaging modalities, including confocal laser endomicroscopy (CLE), may represent an alternative or adjunctive option to delineate tumor footprint and assess for peripheral margin status. We present a case series describing our use of the Cellvizio® probe-based CLE platform as an intraoperative modality to assess for peripheral mucosal margins in the larynx, oropharynx, and hypopharynx during TORS resections using robotic instrumentation to establish basic feasibility and create the groundwork for future investigations of relative efficacy and impact on local recurrence rates.

Authors with CRIS profile

Matti Sievert Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik)

Involved external institutions

Washington University in St. Louis US United States (USA) (US) University of Alabama at Birmingham (UAB) US United States (USA) (US) Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Jeyarajan, H., Chaudhary, I., Fuson, A., James, S., Wodeyar, A., Sievert, M.,... Panuganti, B.A. (2025). Intraoperative optical biopsy assessment during TORS head and neck cancer resections-a novel application of confocal laser endomicroscopy with intravenous fluorescein. Oral Oncology Reports, 13. https://doi.org/10.1016/j.oor.2024.100702

MLA:

Jeyarajan, Harishanker, et al. "Intraoperative optical biopsy assessment during TORS head and neck cancer resections-a novel application of confocal laser endomicroscopy with intravenous fluorescein." Oral Oncology Reports 13 (2025).

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