Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease
Schnizler S, Naumann M, Vieth M (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 163
Article Number: 22
Journal Issue: 1
DOI: 10.1007/s00418-024-02345-2
Abstract
A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies. We analyzed paraffin-embedded gastric tissue samples from 326 patients. A20 expression was assessed using immunohistochemistry (IHC) with results categorized according to the Remmele and Stegner immunoreactive score (IRS). The study compared A20 expression across a spectrum of gastric pathologies, including Helicobacter pylori (HP) gastritis, autoimmune gastritis (A-gastritis), reactive gastropathy (C-gastritis), Ex-HP-gastritis, adenomas, and adenocarcinomas, with nonpathological gastric mucosa serving as a baseline. Our findings demonstrate a significant increase in A20 expression in HP-gastritis (p = 0.019), A-gastritis (p = 0.001), adenomas (p < 0.001), and adenocarcinomas (p < 0.001). Conversely, no significant differences in A20 expression were observed in C-gastritis or Ex-HP-gastritis cases.
Involved external institutions
Germany (DE)How to cite
APA:
Schnizler, S., Naumann, M., & Vieth, M. (2025). Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease. Histochemistry and Cell Biology, 163(1). https://doi.org/10.1007/s00418-024-02345-2
MLA:
Schnizler, Stephan, Michael Naumann, and Michael Vieth. "Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease." Histochemistry and Cell Biology 163.1 (2025).
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