Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa

Dahmardeh M, Dastjerdi HM, Mazal H, Köstler H, Sandoghdar V (2023)

Publication Type: Conference contribution

Publication year: 2023

Publisher: Optical Society of America

Conference Proceedings Title: Bio-Optics: Design and Application in Proceedings Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023

Event location: Vancouver, BC, CAN

ISBN: 9781957171210

DOI: 10.1364/BODA.2023.JW2A.3

Abstract

Interferometric scattering (iSCAT) microscopy detects single nanoparticles in a label-free fashion. Utilizing self-supervised machine learning pushes the detection sensitivity of iSCAT to very small proteins and disease markers such as chemokines and cytokines.

Authors with CRIS profile

Harald Köstler Lehrstuhl für Informatik 10 (Systemsimulation) (LSS) Vahid Sandoghdar

Involved external institutions

Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light DE Germany (DE)

How to cite

APA:

Dahmardeh, M., Dastjerdi, H.M., Mazal, H., Köstler, H., & Sandoghdar, V. (2023). Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa. In Bio-Optics: Design and Application in Proceedings Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023. Vancouver, BC, CAN: Optical Society of America.

MLA:

Dahmardeh, Mahyar, et al. "Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa." Proceedings of the Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver, BC, CAN Optical Society of America, 2023.

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