Sclerosing mucoepidermoid carcinoma of salivary glands

Othman BK, Bradová M, Simpson RH, Laco J, Agaimy A, Rito M, Ihrler S, Steiner P, Grossmann P, Hájková V, de Rezende G, Goma M, Koljenovic S, Fonseca I, Michal M, Leivo I, Skalova A (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Virchows Archiv Springer Verlag (Germany)

DOI: 10.1007/s00428-024-03970-x

Abstract

Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory infiltrate. Herein, we report 25 unpublished cases of SMEC, two of them with prominent eosinophilia (2/25; 8%) and three with abundant IgG4-positive plasma cells (3/25; 12%). In our series of salivary SMEC, molecular analysis using fluorescence in situ hybridization (FISH) and/or next-generation sequencing (NGS) provided evidence of MAML2 gene rearrangement in 18 cases of the 21 analyzable cases tested (86%), while this gene locus was intact in 3 cases (14%). This study focuses on the diagnostic criteria of salivary SMEC given its challenge of abundant collagenous stroma, minimal residual neoplastic areas, and inconspicuous mucous cells. Follow-up data of our cases indicate that salivary SMECs have favorable outcomes. Molecular analysis for MAML2 gene rearrangement suggests that SMECs of salivary glands represent a rare variant of conventional low-grade MECs of salivary glands. In contrast, SMECs of the thyroid gland are genetically distinct from salivary-type thyroid MECs.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Bellvitge University Hospital / Hospital Universitari de Bellvitge ES Spain (ES) Hospital Network Antwerp / Ziekenhuis Netwerk Antwerpen (ZNA) BE Belgium (BE) Biopticka laborator s.r.o. CZ Czech Republic (CZ) Ospedale Niguarda Ca' Granda / ASST Grande Ospedale Metropolitano Niguarda IT Italy (IT) University of Lisbon / Universidade de Lisboa (ULisboa) PT Portugal (PT) Univerzita Karlova v Praze / Charles University in Prague CZ Czech Republic (CZ) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) FI Finland (FI) University of Calgary CA Canada (CA) University Hospital Hradec Králové / Fakultní Nemocnice Hradec Králové CZ Czech Republic (CZ) LMU Klinikum DE Germany (DE)

How to cite

APA:

Othman, B.K., Bradová, M., Simpson, R.H., Laco, J., Agaimy, A., Rito, M.,... Skalova, A. (2024). Sclerosing mucoepidermoid carcinoma of salivary glands. Virchows Archiv. https://doi.org/10.1007/s00428-024-03970-x

MLA:

Othman, Bacem Khalele, et al. "Sclerosing mucoepidermoid carcinoma of salivary glands." Virchows Archiv (2024).

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