Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems

Almahayni K, Bachir Salvador J, Conti R, Widera A, Spiekermann M, Wehner D, Grützmacher H, Möckl L (2024)

Publication Type: Journal article

Publication year: 2024

Journal

DOI: 10.1021/acschembio.4c00399

Abstract

Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current chemical platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we report on the synthesis of a structurally versatile library of chemically tunable bisacylphosphane oxides (BAPOs), which harnesses the spatiotemporal precision of light delivery, thereby establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light Germany (DE) Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich Switzerland (CH)

How to cite

APA:

Almahayni, K., Bachir Salvador, J., Conti, R., Widera, A., Spiekermann, M., Wehner, D.,... Möckl, L. (2024). Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems. ACS Chemical Biology. https://doi.org/10.1021/acschembio.4c00399

MLA:

Almahayni, Karim, et al. "Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems." ACS Chemical Biology (2024).

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