Flavonoids from eupatorium illitum and their antiproliferative activities
Castillo QA, Triana J, Eiroa JL, Padrón JM, Plata GB, Abel-Santos EV, Báez LA, Rodríguez DC, Jiménez MA, Pérez-Pujols MF (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 7
Pages Range: 178-181
Journal Issue: 3
DOI: 10.5530/pj.2015.3.6
Abstract
Objective: To isolate the chemical constituents of the aerial parts from Eupatorium illitum, elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. Materials and Methods: The ethanolic extract of Eupatorium illitum afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated. Results: The flavonoids Kumatakenin (1), Ermanin (2), 7-methoxy- Aromadendrin (3) and Naringenin (4), together with 4-hydroxybenzoic acid (5) were isolated. Compounds 1, 2, 4 and 5 were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for 5. Conclusion: Compounds 1-5 are reported for first time from Eupatorium illitum. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.
Authors with CRIS profile
Involved external institutions
Autonomous University of Santo Domingo / Universidad Autónoma de Santo Domingo (UASD)
Dominican Republic (DO)
Universidad de Las Palmas Gran Canaria
Spain (ES)
Universidad de La Laguna
Spain (ES)
University of Nevada Las Vegas
United States (USA) (US)
Dominican Republic (DO)
Universidad de Las Palmas Gran Canaria
Spain (ES)
Universidad de La Laguna
Spain (ES)
University of Nevada Las Vegas
United States (USA) (US)
How to cite
APA:
Castillo, Q.A., Triana, J., Eiroa, J.L., Padrón, J.M., Plata, G.B., Abel-Santos, E.V.,... Pérez-Pujols, M.F. (2015). Flavonoids from eupatorium illitum and their antiproliferative activities. Pharmacognosy Journal, 7(3), 178-181. https://doi.org/10.5530/pj.2015.3.6
MLA:
Castillo, Quírico A., et al. "Flavonoids from eupatorium illitum and their antiproliferative activities." Pharmacognosy Journal 7.3 (2015): 178-181.
BibTeX: Download