Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study)

Passoke S, Stern C, Häußler V, Kümpfel T, Havla J, Engels D, Jarius S, Wildemann B, Korporal-Kuhnke M, Senel M, Stellmann JP, Warnke C, Grothe M, Schülke R, Gingele S, Kretschmer JR, Klotz L, Walter A, Bergh FT, Aktas O, Ringelstein M, Ayzenberg I, Schwake C, Kleiter I, Sperber PS, Rust R, Schindler P, Bellmann-Strobl J, Paul F, Kopp B, Trebst C, Hümmert MW, Albrecht P, Angstwurm K, Asseyer S, Bayas A, Bednarz N, Behnke S, Berthele A, Bittner S, Bütow F, Buttmann M, Dawin E, Dersch R, Duchow A, Etgen T, Finke C, Fischer K, Förster M, Fousse M, Frank B, Freitag F, Gahlen A, Gass A, Gehrig J, Geis C, Giglhuber K, Goereci Y, Gold R, Gomes ABAGR, Graf J, Groppa S, Gutbrod J, Guthke K, Haarmann A, Hastermann M, Hellwig K, Hemmer B, Herfurth M, Herwerth M, Hoffmann F, Hoffmann O, Hofstadt-Van Oy U, Husseini L, Ingenhoven K, Junghans J, Kaste M, Kern K, Kern P, Kermer P, Kleinschnitz C, Köhler W, Körbel K, Kowarik M, Krämer M, Krumbholz M, Kunzmann V, Kurka N, Ladopoulos T, Landwehr A, Langel S, Lauenstein AS, Laurent S, Lee DH, Lehrieder D, Leypoldt F, Liebetrau M, Lindenblatt G, Linker R, Lohmann L, Lüdemann P, Luessi F, Maiworm M, Marziniak M, Mayer C, Meister S, Melms A, von Mering M, Metz I, Meuth S, Naumann J, Nenkov M, Neuhaus O, Neziraj T, Niederschweiberer M, Niehaus S, Oertel FC, Otto C, Pache F, Pakeerathan T, Paryjas S, Pawlitzki M, Pepping S, Pfeuffer S, Pompsch M, Pretzsch RA, Proebstel AK, Protopapa M, Puhlmann HU, Pul R, Rauer S, Rehfeldt T, Retzlaff N, Riedlinger A, Rommer P, Rostásy K, Rothhammer V, Rückriem L, Ruprecht K, Ruschil C, Saggau C, Schraad M, Schwab M, Schwarz P, Seipelt M, Sieb JP, Soloroza G, Sommer C, Stefanou A, Steinbrecher A, Stephanik H, Steuerwald V, Stoppe M, Stürner K, Süße M, Tarampanis A, Tauber S, Tkachenko D, Tsaktanis T, Tumani H, Wallwitz U, Walz A, Wandinger KP, Weber MS, Weise J, Wickel J, Wiendl H, Winkelmann A, Wohlrab F, Yalachkov Y, Zettl U, Ziemann U, Zipp F (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Article Number: jnnp-2024-333994

DOI: 10.1136/jnnp-2024-333994

Abstract

Background Data on cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited to studies with small sample sizes. Therefore, we aimed to analyse the extent, characteristics and the longitudinal course of potential cognitive deficits in patients with MOGAD. Methods The CogniMOG-Study is a prospective, longitudinal and multicentre observational study of 113 patients with MOGAD. Individual cognitive performance was assessed using the Paced Auditory Serial Addition Task (PASAT), the Symbol Digit Modalities Test (SDMT) and the Multiple Sclerosis Inventory Cognition (MuSIC), which are standardised against normative data from healthy controls. Cognitive performance was assessed at baseline and at 1-year and 2-year follow-up assessments. Multiple linear regression was used to analyse demographic and clinical predictors of cognitive deficits identified in previous correlation analyses. Results At baseline, the study sample of MOGAD patients showed impaired standardised performance on MuSIC semantic fluency (mean=-0.29, 95% CI (-0.47 to -0.12)) and MuSIC congruent speed (mean=-0.73, 95% CI (-1.23 to -0.23)). Around 1 in 10 patients showed deficits in two or more cognitive measures (11%). No decline in cognition was observed during the 1-year and 2-year follow-up period. Cerebral lesions were found to be negatively predictive for SDMT (B=-8.85, 95% CI (-13.57 to -4.14)) and MuSIC semantic fluency (B=-4.17, 95% CI (-6.10 to -2.25)) test performance. Conclusions Based on these data, we conclude that MOGAD patients show reduced visuomotor processing speed and semantic fluency to the extent that the disease burden includes cerebral lesions.

Authors with CRIS profile

Involved external institutions

Universitätsmedizin Rostock Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Klinikum der Universität München (LMU Klinikum) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Universität Ulm Germany (DE) Kliniken Maria Hilf GmbH Germany (DE) Universitätsklinikum Regensburg Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsklinikum Leipzig Germany (DE) Knappschaftsklinikum Saar Germany (DE) Technische Universität München (TUM) Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Caritas-Krankenhaus Bad Mergentheim gemeinnützige GmbH Germany (DE) Universitätsklinikum Münster Germany (DE) Universitätsklinikum Freiburg Germany (DE) Kliniken Südostbayern AG Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Universitätsklinikum Essen Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim) Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Universitätsklinikum Jena Germany (DE) Universitätsklinikum Köln Germany (DE) Universitätsspital Basel Switzerland (CH) Städtisches Klinikum Görlitz Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Universitätsspital Zürich (USZ) Switzerland (CH) Klinikum Westfalen Germany (DE) Universitätsklinikum Göttingen Germany (DE) Nordwest-Krankenhaus Sanderbusch Germany (DE) Katholisches Klinikum Bochum (St. Josef- und St. Elisabeth-Hospital gGmbH) Germany (DE) Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) Germany (DE) Asklepios Kliniken Germany (DE) Universitätsklinikum Tübingen Germany (DE) Alfried Krupp Krankenhaus Germany (DE) Immanuel Klinik Rüdersdorf Germany (DE) Landeskrankenhaus (AöR) Germany (DE) HELIOS Kliniken Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) St. Josefs-Hospital Wiesbaden Germany (DE) Agaplesion Ev. Bathildiskrankenhaus Germany (DE) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE) Klinikum Herford Germany (DE) Universität Leipzig Germany (DE) Isar-Amper-Hospital Germany (DE) Klinikum Bremen-Nord Germany (DE) SRH Kliniken Landkreis Sigmaringen GmbH Germany (DE) Klinikum Dortmund Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Schlosspark-Klinik Germany (DE) Dietrich-Bonhoeffer-Klinikum Germany (DE) Universität Wien / University of Vienna Austria (AT) Vestische Caritas-Kliniken GmbH Germany (DE) MediClin Hedon Klinik Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Würzburg Germany (DE) Katharinenhospital Stuttgart Germany (DE) Universitätsklinikum Magdeburg A.ö.R. Germany (DE)

How to cite

APA:

Passoke, S., Stern, C., Häußler, V., Kümpfel, T., Havla, J., Engels, D.,... Zipp, F. (2024). Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study). Journal of Neurology Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2024-333994

MLA:

Passoke, Sarah, et al. "Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study)." Journal of Neurology Neurosurgery and Psychiatry (2024).

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