The effect of mesoporous bioactive glass nanoparticles incorporating various metallic ions (Cu, Zn, Mn, Te) on wound healing

Pourshahrestani S, Zeimaran E, Janko C, Alexiou C, Kerpes A, Würz A, Fischer M, Kaňková H, Hartmann M, Boccaccini AR (2024)

Publication Language: English

Publication Type: Journal article

Publication year: 2024

Journal

Materials Advances Royal Society of Chemistry (RSC)

Book Volume: 5

Pages Range: 6630-6647

Journal Issue: 16

DOI: 10.1039/d4ma00392f

Abstract

Recently, mesoporous bioactive glasses (MBGs) as microparticles or nanoparticles (MBGNs) aroused a great interest owing to their high textural properties and capability to be incorporated with biologically active ions desirable for different stages of wound healing. Considering therapeutic effects of two well-recognized elements (copper and zinc) as well as two less-common elements (manganese and tellurium), in this study, different concentrations of these elements were incorporated into SiO2-CaO MBGNs and their potential for wound healing applications was assessed in vitro. While at a concentration of 5 mg ml−1, the extracts of some MBGNs reduced E. coli and S. aureus bacteria viabilities, normal human dermal fibroblast (NHDF) cell viabilities were negatively affected with extracts of Cu-MBGNs and Te-MBGNs. The nanoparticles also affected hemolysis in a donor-dependent manner and the incorporation of Te into the MBGNs networks increased the hemolysis ratio to more than 5%. Moreover, some of the nanoparticles at concentration of 1 mg ml−1 shortened activated partial thromboplastin time (aPTT) insignificantly compared to pure platelet poor plasma. At higher concentrations of therapeutic elements, the extracts of nanoparticles resulted in the significant slower migration of NHDF cells in the scratch area. The effects of the nanoparticles and their extracts on blood coagulation and NHDF cell migration are thus dependent on the composition and/or applied concentration of nanoparticles. The present results provide information for the design of MBGN compositions of interest for wound healing and highlight the importance of optimization of the nanoparticles dosage and therapeutic ion concentration for acceleration of the wound healing process.

Authors with CRIS profile

Sara Pourshahrestani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Ehsan Zeimaran Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Christina Janko Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Christoph Alexiou Professur für Nanomedizin Adrian Würz Interface Research and Catalysis (ECRC) Marcus Fischer Interface Research and Catalysis (ECRC) Martin Hartmann Professur für Katalyse Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Additional Organisation(s)

FAU Forschungszentrum Neue Wirkstoffe (FAU NeW)

Involved external institutions

Trenčianska univerzita Alexandra Dubčeka v Trenčíne SK Slovakia (SK)

How to cite

APA:

Pourshahrestani, S., Zeimaran, E., Janko, C., Alexiou, C., Kerpes, A., Würz, A.,... Boccaccini, A.R. (2024). The effect of mesoporous bioactive glass nanoparticles incorporating various metallic ions (Cu, Zn, Mn, Te) on wound healing. Materials Advances, 5(16), 6630-6647. https://doi.org/10.1039/d4ma00392f

MLA:

Pourshahrestani, Sara, et al. "The effect of mesoporous bioactive glass nanoparticles incorporating various metallic ions (Cu, Zn, Mn, Te) on wound healing." Materials Advances 5.16 (2024): 6630-6647.

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