Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals
Müller P, Sack A, Dümler J, Heckel M, Wenzel T, Siegert T, Schuldt-Lieb S, Gieseler H, Pöschel T (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 25
Article Number: 143
Journal Issue: 6
DOI: 10.1208/s12249-024-02833-7
Abstract
The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals. Consequently, visual quality control of the product is imperative. However, this procedure is not only time-consuming and labor-intensive but also expensive and prone to errors. In this paper, we present an approach for fully automated, non-destructive inspection of freeze-dried pharmaceuticals, leveraging robotics, computed tomography, and machine learning.
Authors with CRIS profile
Patric Müller
Lehrstuhl für Multiscale Simulation of Particulate Systems (MSS)
Achim Sack
Lehrstuhl für Multiscale Simulation of Particulate Systems (MSS)
Jens Dümler
Sonderforschungsbereich 1411 Produktgestaltung disperser Systeme / Design of Particulate Products
Michael Heckel
Lehrstuhl für Multiscale Simulation of Particulate Systems (MSS)
Tim Wenzel
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Teresa Siegert
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Thorsten Pöschel
Lehrstuhl für Multiscale Simulation of Particulate Systems (MSS)
Involved external institutions
Germany (DE)How to cite
APA:
Müller, P., Sack, A., Dümler, J., Heckel, M., Wenzel, T., Siegert, T.,... Pöschel, T. (2024). Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals. Aaps Pharmscitech, 25(6). https://doi.org/10.1208/s12249-024-02833-7
MLA:
Müller, Patric, et al. "Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals." Aaps Pharmscitech 25.6 (2024).
BibTeX: Download