Synthesis of New Highly Functionalized Quinolines via a Novel Fe III -Catalyzed Domino aza-Michael/Aldol/Aromatization Reaction

Heckmann F, Ibrahim M, Hampel F, Tsogoeva S (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Synlett Thieme Publishing / Georg Thieme Verlag

Book Volume: 35

Pages Range: 1007-1010

Journal Issue: 9

DOI: 10.1055/s-0042-1751546

Abstract

We report the development of a straightforward, waste-reducing, environmentally friendly, FeIII-catalyzed domino aza-Michael/aldol/ aromatization reaction in the presence of water to access high-value functionalized quinolines by using 2-aminobenzophenones and ethyl buta-2,3-dienoate as starting compounds. The tangible advantages, that is, the utilization of commercially available and/or easily accessible substrates, simplicity, mild reaction conditions, and application of water as a solvent, make this three-step domino process green and highly appealing for the direct construction of a wide variety of highly functionalized quinolines in up to 78% yield.

Authors with CRIS profile

Felix Heckmann Lehrstuhl für Organische Chemie I Mohammad Ibrahim Professur für Organische Chemie Frank Hampel Lehrstuhl für Organische Chemie I Svetlana Tsogoeva Professur für Organische Chemie

How to cite

APA:

Heckmann, F., Ibrahim, M., Hampel, F., & Tsogoeva, S. (2024). Synthesis of New Highly Functionalized Quinolines via a Novel Fe III -Catalyzed Domino aza-Michael/Aldol/Aromatization Reaction. Synlett, 35(9), 1007-1010. https://doi.org/10.1055/s-0042-1751546

MLA:

Heckmann, Felix, et al. "Synthesis of New Highly Functionalized Quinolines via a Novel Fe III -Catalyzed Domino aza-Michael/Aldol/Aromatization Reaction." Synlett 35.9 (2024): 1007-1010.

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