Unlocking the potential of iron-containing mesoporous bioactive glasses: Orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts

Zhou T, Xu Z, Sun H, Beltrán AM, Nawaz Q, Sui B, Boccaccini AR, Zheng K (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Colloids and Surfaces A-Physicochemical and Engineering Aspects Elsevier

Book Volume: 694

Article Number: 134188

DOI: 10.1016/j.colsurfa.2024.134188

Abstract

Iron (Fe) is a crucial element in the human body, playing a significant role in bone metabolism. The release of Fe ions at bone defect sites can promote bone regeneration. In this study, we synthesized Fe-containing mesoporous bioactive glasses (Fe-MBGs) in SiO2-CaO-Fe2O3 composition using a sol-gel method. Regardless of the amount of incorporated Fe2O3 (up to 5 mol%), the Fe-MBGs maintained a mesoporous structure, and the inclusion of Fe2O3 did not alter their amorphous characteristics. However, the presence of Fe2O3 led to a reduction in both pore volume and specific surface area of Fe-MBGs. Notably, Fe-MBGs demonstrated degradability in physiological fluids and could sustain release of Si, Fe, and Ca ions. Higher concentrations of incorporated Fe2O3 were found to reduce the degradation of Fe-MBGs. All Fe-MBGs exhibited favorable bioactivity, as evidenced by the rapid formation of hydroxyapatite when exposed to simulated body fluid. Fe-MBGs also demonstrated concentration-dependent effects on BMSCs and Saos-2 cells. Extracts of Fe-MBGs at 0.1 and 1 mg/mL exhibited non-cytotoxicity and promoted cell proliferation. Additionally, extracts of Fe-MBGs at 1 mg/mL significantly enhanced the alkaline phosphatase activity of BMSCs and Saos-2 cells, along with an upregulation of the expression of osteogenesis-related genes. These findings unlock the significant potential of Fe-MBGs as functional biomaterials for bone regeneration applications. The controlled release of Fe ions from these mesoporous bioactive glasses orchestrates osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts.

Authors with CRIS profile

Qaisar Nawaz Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Additional Organisation(s)

FAU Forschungszentrum Neue Wirkstoffe (FAU NeW)

Involved external institutions

Shanghai Ninth People's Hospital (Bethel Hospital) CN China (CN) Shanghai Jiao Tong University / 上海交通大学 CN China (CN) Nanjing Medical University / 南京医科大学 CN China (CN) University of Seville / Universidad de Sevilla ES Spain (ES)

How to cite

APA:

Zhou, T., Xu, Z., Sun, H., Beltrán, A.M., Nawaz, Q., Sui, B.,... Zheng, K. (2024). Unlocking the potential of iron-containing mesoporous bioactive glasses: Orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 694. https://doi.org/10.1016/j.colsurfa.2024.134188

MLA:

Zhou, Tian, et al. "Unlocking the potential of iron-containing mesoporous bioactive glasses: Orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts." Colloids and Surfaces A-Physicochemical and Engineering Aspects 694 (2024).

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