Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
Schödel J, Bardella C, Sciesielski LK, Brown JM, Pugh CW, Buckle V, Tomlinson IP, Ratcliffe PJ, Mole DR (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 44
Pages Range: 420-425
Journal Issue: 4
DOI: 10.1038/ng.2204
Abstract
Although genome-wide association studies (GWAS) have identified the existence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited, particularly for intergenic polymorphisms. Here, we show that polymorphism at a remote intergenic region on chromosome 11q13.3, recently identified as a susceptibility locus for renal cell carcinoma, modulates the binding and function of hypoxia-inducible factor (HIF) at a previously unrecognized transcriptional enhancer of CCND1 (encoding cyclin D1) that is specific for renal cancers characterized by inactivation of the von Hippelg-Lindau tumor suppressor (pVHL). The protective haplotype impairs binding of HIF-2, resulting in an allelic imbalance in cyclin D1 expression, thus affecting a link between hypoxia pathways and cell cycle control. © 2012 Nature America, Inc. All rights reserved.
Involved external institutions
Wellcome Centre for Human Genetics
United Kingdom (GB)
University of Oxford
United Kingdom (GB)
MRC Weatherall Institute Of Molecular Medicine
United Kingdom (GB)
United Kingdom (GB)
University of Oxford
United Kingdom (GB)
MRC Weatherall Institute Of Molecular Medicine
United Kingdom (GB)
How to cite
APA:
Schödel, J., Bardella, C., Sciesielski, L.K., Brown, J.M., Pugh, C.W., Buckle, V.,... Mole, D.R. (2012). Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nature Genetics, 44(4), 420-425. https://doi.org/10.1038/ng.2204
MLA:
Schödel, Johannes, et al. "Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression." Nature Genetics 44.4 (2012): 420-425.
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