Pan-genomic binding of hypoxia-inducible transcription factors

Schödel J, Mole DR, Ratcliffe PJ (2013)

Publication Type: Journal article, Review article

Publication year: 2013

Journal

Biological Chemistry Walter de Gruyter

Book Volume: 394

Pages Range: 507-517

Journal Issue: 4

DOI: 10.1515/hsz-2012-0351

Abstract

Hypoxia-inducible transcription factors (HIFs) mediate the cellular response to hypoxia. HIF-DNA binding triggers a transcriptional program that acts to both restore oxygen homeostasis and adapt cells to low oxygen availability. In this context, HIF is centrally involved in many physiologic and pathophysiological processes such as development, high altitude adaptation, ischemic disease, inflammation, and cancer. The recent development of chromatin immunoprecipitation coupled to genomewide DNA sequence analysis allows the position and extent of HIF binding to DNA to be characterized across the entire genome and correlated with genetic, epigenetic, and transcriptional analyses. This review summarizes recent pan-genomic analyses of HIF binding and HIFdependent transcriptional regulation.

Authors with CRIS profile

Johannes Schödel Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

University of Oxford GB United Kingdom (GB)

How to cite

APA:

Schödel, J., Mole, D.R., & Ratcliffe, P.J. (2013). Pan-genomic binding of hypoxia-inducible transcription factors. Biological Chemistry, 394(4), 507-517. https://doi.org/10.1515/hsz-2012-0351

MLA:

Schödel, Johannes, David Robert Mole, and Peter John Ratcliffe. "Pan-genomic binding of hypoxia-inducible transcription factors." Biological Chemistry 394.4 (2013): 507-517.

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