Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study

Moreno-González R, Cruzado JM, Corsonello A, Fabbietti P, Tap L, Mattace-Raso F, Ärnlöv J, Carlsson AC, Guligowska A, Kostka T, Artzi-Medvedik R, Melzer I, Roller-Wirnsberger R, Wirnsberger G, Kob R, Sieber C, Lattanzio F, Formiga F (2024)

Publication Type: Journal article

Publication year: 2024

Journal

European Journal of Internal Medicine Elsevier

Book Volume: 123

Pages Range: 81-93

DOI: 10.1016/j.ejim.2023.12.002

Abstract

Aim: Sarcopenia is associated with several factors and medical conditions among older adults, though previous research has shown limitations and inconsistencies, especially regarding chronic kidney disease (CKD). We investigated the clinical and laboratory variables associated with sarcopenia and severe sarcopenia in older adults, focusing on kidney function measures. Methods: Data from community-dwelling adults aged ≥75 years participating in the SCOPE multicenter prospective cohort study were assessed cross-sectionally. Comprehensive geriatric assessment was conducted; sociodemographic and lifestyle factors, clinical variables and comorbidities, anthropometric and bioelectrical impedance analysis, blood and urine laboratory variables were collected. EWGSOP2 revised criteria were used to define sarcopenia and its severity. Estimated glomerular filtration rate (eGFR) was calculated using creatinine and non-creatinine-based equations, and CKD stages were defined accordingly. Results: 1420 participants were included, prevalence of sarcopenia was 10.6 %, and 6 % had severe sarcopenia. Multivariate logistic regression analysis showed that age [OR =1.14; 95 %CI (1.09–1.19)], body mass index (BMI) [0.83 (0.79–0.88)], disability performing instrumental activities of daily living (IADL) [2.61 (1.69–4.06)], Mini Mental State Examination (MMSE) score <24 [2.75 (1.62–4.67)], osteoporosis [2.39 (1.55–3.67)], and stage 4 CKD defined by CKD-EPIBTP-B2M, a non-creatinine-based eGFR equation [2.88 (1.11–7.49)], were independently associated with sarcopenia; as were specifically with severe sarcopenia, with more pronounced associations. Conclusions: In community-dwelling older adults, sarcopenia is a relevant condition and is associated with severe CKD, older age, IADL, cognitive impairments, osteoporosis and low BMI. These factors should be assessed for proper identification and management of older patients with sarcopenia, and even more so with severe sarcopenia.

Authors with CRIS profile

Robert Kob Lehrstuhl für Innere Medizin (Geriatrie) Cornel Sieber Lehrstuhl für Innere Medizin (Geriatrie)

Involved external institutions

Bellvitge University Hospital / Hospital Universitari de Bellvitge ES Spain (ES) Bellvitge Biomedical Research Institute (IDIBELL) ES Spain (ES) Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA) IT Italy (IT) Erasmus University Medical Center (MC) NL Netherlands (NL) Dalarna University College SE Sweden (SE) Karolinska Institute SE Sweden (SE) Medical University of Łódź / Uniwersytet Medyczny w Łodzi PL Poland (PL) Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב IL Israel (IL) Medizinische Universität Graz AT Austria (AT)

How to cite

APA:

Moreno-González, R., Cruzado, J.M., Corsonello, A., Fabbietti, P., Tap, L., Mattace-Raso, F.,... Formiga, F. (2024). Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study. European Journal of Internal Medicine, 123, 81-93. https://doi.org/10.1016/j.ejim.2023.12.002

MLA:

Moreno-González, Rafael, et al. "Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study." European Journal of Internal Medicine 123 (2024): 81-93.

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