Serotonin Signaling through Lipid Membranes
Kalinichenko L, Kornhuber J, Sinning S, Haase J, Müller CP (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Journal
Book Volume: 15
Pages Range: 1298-1320
Journal Issue: 7
DOI: 10.1021/acschemneuro.3c00823
Abstract
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release, receptor activation, and inactivation are critical to 5-HT signaling in synaptic and extra-synaptic sites. Moreover, these signals represent information transmission across membranes. Although the lipid membrane environment is often viewed as fairly stable, emerging research suggests significant functional lipid-protein interactions with many synaptic 5-HT proteins. These protein-lipid interactions extend to almost all the primary lipid classes that form the plasma membrane. Collectively, these lipid classes and lipid-protein interactions affect 5-HT synaptic efficacy at the synapse. The highly dynamic lipid composition of synaptic membranes suggests that these lipids and their interactions with proteins may contribute to the plasticity of the 5-HT synapse. Therefore, this broader protein-lipid model of the 5-HT synapse necessitates a reconsideration of 5-HT’s role in various associated mental disorders.
Authors with CRIS profile
Liubov Kalinichenko
Department of Psychiatry and Psychotherapy
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Peter Christian Müller
Professur für Suchtmedizin
Involved external institutions
Denmark (DK)
Ireland (IE)How to cite
APA:
Kalinichenko, L., Kornhuber, J., Sinning, S., Haase, J., & Müller, C.P. (2024). Serotonin Signaling through Lipid Membranes. ACS Chemical Neuroscience, 15(7), 1298-1320. https://doi.org/10.1021/acschemneuro.3c00823
MLA:
Kalinichenko, Liubov, et al. "Serotonin Signaling through Lipid Membranes." ACS Chemical Neuroscience 15.7 (2024): 1298-1320.
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