The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Carucci S, Zuddas A, Lampis A, Man KK, Balia C, Buitelaar J, Danckaerts M, Dittmann RW, Donno F, Falissard B, Gagliano A, Garas P, Häge A, Hollis C, Inglis SK, Konrad K, Kovshoff H, Liddle E, McCarthy S, Neubert A, Nagy P, Rosenthal E, Sonuga-Barke EJ, Wong IC, Banaschewski T, Coghill D (2024)

Publication Language: English

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 28

Pages Range: 722-739

Journal Issue: 5

DOI: 10.1177/10870547241226726

Abstract

Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

Authors with CRIS profile

Involved external institutions

University of Nottingham United Kingdom (GB) University of Dundee United Kingdom (GB) Universitätsklinikum Aachen (UKA) Germany (DE) University of Southampton United Kingdom (GB) University College Cork (UCC) Ireland (IE) Bethesda Children’s Hospital / Bethesda Kórház Alapítvány Hungary (HU) Evelina London Children's Hospital United Kingdom (GB) King’s College London United Kingdom (GB) University College London (UCL) United Kingdom (GB) Ruprecht-Karls-Universität Heidelberg Germany (DE) Università degli Studi di Cagliari Italy (IT) Donders Institute for Brain, Cognition and Behaviour Netherlands (NL) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Université Paris-Saclay France (FR) University of Messina / Università degli Studi di Messina Italy (IT) Semmelweis University / Semmelweis Egyetem Hungary (HU)

How to cite

APA:

Carucci, S., Zuddas, A., Lampis, A., Man, K.K., Balia, C., Buitelaar, J.,... Coghill, D. (2024). The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project. Journal of Attention Disorders, 28(5), 722-739. https://doi.org/10.1177/10870547241226726

MLA:

Carucci, Sara, et al. "The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project." Journal of Attention Disorders 28.5 (2024): 722-739.

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