The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients
Kamińska J, Tylicka M, Sutkowska K, Gacuta KM, Sawicka MM, Kowalewska E, Ćwiklińska-Dworakowska M, Maciejczyk M, Łysoń T, Kornhuber J, Lewczuk P, Matowicka-Karna J, Koper-Lenkiewicz OM (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 14
Article Number: 3941
Journal Issue: 1
DOI: 10.1038/s41598-024-54692-8
Abstract
The significant role of increased activation of 20S proteasomes in the development of abdominal aortic aneurysms has been well-established in a mouse model. The available literature lacks similar studies concerning brain aneurysms. The aim of the study was to verify the hypothesis that patients with unruptured intracranial aneurysms (UIA) have increased 20S proteasome ChT-L activity compared to the control group of individuals without vascular lesions in the brain. In the next step, the relationship between the activity of 20S proteasomes ChT-L and precursor proteins from the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) family, namely NF-κB1 (p105), NF-κB2 (p100), NF-κB p65, and the inflammatory chemokine MCP-1, was examined. Patients with UIA had significantly higher 20S ChT-L proteasome activity compared to the control group. Patients with multiple aneurysms had significantly higher 20S proteasome ChT-L activity compared to those with single aneurysms. In patients with UIA, the activity of the 20S proteasome ChT-L negatively correlated with the concentration of NF-κB1 (p105) and NF-κB p65 precursor proteins and positively correlated with the concentration of the cerebrospinal fluid chemokine MCP-1. Our results may suggest that increased 20S proteasome ChT-L activity in UIA patients modulates inflammation in the cerebral arterial vessel via the MCP-1 chemokine as a result of activation of the canonical NF-κB pathway.
Authors with CRIS profile
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Piotr Lewczuk
Department of Psychiatry and Psychotherapy
Involved external institutions
Medical University of Bialystok
Poland (PL)
Medical University of Bialystok Clinical Hospital / Uniwersytecki Szpital Kliniczny w Białymstoku
Poland (PL)
Poland (PL)
Medical University of Bialystok Clinical Hospital / Uniwersytecki Szpital Kliniczny w Białymstoku
Poland (PL)
How to cite
APA:
Kamińska, J., Tylicka, M., Sutkowska, K., Gacuta, K.M., Sawicka, M.M., Kowalewska, E.,... Koper-Lenkiewicz, O.M. (2024). The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients. Scientific Reports, 14(1). https://dx.doi.org/10.1038/s41598-024-54692-8
MLA:
Kamińska, Joanna, et al. "The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients." Scientific Reports 14.1 (2024).
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