Production of interferon-γ by myeloid cells - fact or fancy?
Bogdan C, Schleicher U (2006)
Publication Type: Journal article, Review article
Publication year: 2006
Journal
Book Volume: 27
Pages Range: 282-290
Journal Issue: 6
Abstract
Myeloid cells are usually viewed as targets rather than producers of interferon (IFN)-γ. However, since 1993 several studies have suggested that macrophages and dendritic cells can also secrete IFN-γ in response to various stimuli, which led to the idea of autocrine myeloid-cell activation in innate immunity. Here, we review this concept in the light of recent findings that illustrate the necessity of specific cell markers, cell purity, sensitive single-cell cytokine detection methods, and of further insights into the developmental origin of myeloid and lymphoid cell lineages. We also discuss the possible function of intracellular IFN-γ in macrophages and the evidence for a protective role of myeloid IFN-γ in vivo. © 2006 Elsevier Ltd. All rights reserved.
Involved external institutions
Germany (DE)How to cite
APA:
Bogdan, C., & Schleicher, U. (2006). Production of interferon-γ by myeloid cells - fact or fancy? Trends in Immunology, 27(6), 282-290. https://doi.org/10.1016/j.it.2006.04.004
MLA:
Bogdan, Christian, and Ulrike Schleicher. "Production of interferon-γ by myeloid cells - fact or fancy?" Trends in Immunology 27.6 (2006): 282-290.
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