SARS-CoV-2 Infection in Pregnancy and Incidence of Congenital Malformations - Is there a Correlation? Analysis of 8032 Pregnancies from the CRONOS Registry SARS-CoV-2-Infektion in der Schwangerschaft und Auftreten von angeborenen Fehlbildungen - Besteht ein Zusammenhang? Auswertung von 8032 Schwangerschaften aus dem CRONOS-Register

Hofbauer A, Schneider H, Kehl S, Reutter HM, Pecks U, Andresen K, Morhart P (2024)

Publication Language: German

Publication Type: Journal article, Original article

Publication year: 2024

Journal

Zeitschrift für Geburtshilfe und Neonatologie Georg Thieme Verlag

Book Volume: 228

Pages Range: 65-73

Journal Issue: 1

DOI: 10.1055/a-2213-1506

Abstract

Background Based on single case reports, the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS) registry, sponsored by the German Society for Perinatal Medicine (DGPM), investigated the likelihood that SARS-CoV-2 infections of the mother in (early) pregnancy cause embryopathies and/or fetopathies. Material/Methods The CRONOS registry enrolled a total of 8032 women with confirmed SARS-CoV-2 infection during pregnancy at more than 130 participating hospitals from April 2020 to February 2023. Both maternal and fetal data were documented and the anonymized multicenter data were analyzed. Results Of 7142 fully documented pregnancies (including postnatal data), 140 showed congenital malformations. 8.57% of the mothers had had a SARS-CoV-2-infection in the 1st trimester and 36.43% in the 2nd trimester. In 66 cases with congenital malformations (47.14%), the malformation was only detected after the diagnosis of a maternal SARS-CoV-2 infection. The overall prevalence of congenital malformations in this cohort was 1.96%, compared to a prevalence of 2.39% reported in the EUROCAT (European network of population-based registries for the epidemiological surveillance of congenital anomalies) pre-pandemic registry between 2017-2019. Discussion Our multicenter data argue against a link between maternal SARS-CoV-2 infection in early pregnancy and congenital malformation.

Authors with CRIS profile

Holm Schneider Professur für Kinderheilkunde/Experimentelle Perinatalmedizin Sven Kehl Department of Obstetrics and Gynaecology Heiko Martin Reutter Professur für Neonatologie

Involved external institutions

Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE)

How to cite

APA:

Hofbauer, A., Schneider, H., Kehl, S., Reutter, H.M., Pecks, U., Andresen, K., & Morhart, P. (2024). SARS-CoV-2 Infection in Pregnancy and Incidence of Congenital Malformations - Is there a Correlation? Analysis of 8032 Pregnancies from the CRONOS Registry SARS-CoV-2-Infektion in der Schwangerschaft und Auftreten von angeborenen Fehlbildungen - Besteht ein Zusammenhang? Auswertung von 8032 Schwangerschaften aus dem CRONOS-Register. Zeitschrift für Geburtshilfe und Neonatologie, 228(1), 65-73. https://dx.doi.org/10.1055/a-2213-1506

MLA:

Hofbauer, Anna, et al. "SARS-CoV-2 Infection in Pregnancy and Incidence of Congenital Malformations - Is there a Correlation? Analysis of 8032 Pregnancies from the CRONOS Registry SARS-CoV-2-Infektion in der Schwangerschaft und Auftreten von angeborenen Fehlbildungen - Besteht ein Zusammenhang? Auswertung von 8032 Schwangerschaften aus dem CRONOS-Register." Zeitschrift für Geburtshilfe und Neonatologie 228.1 (2024): 65-73.

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