ILAE neuroimaging task force highlight: Subcortical laminar heterotopia

Kasper BS, Archer J, Bernhardt BC, Caciagli L, Cendes F, Chinvarun Y, Concha L, Federico P, Gaillard W, Kobayashi E, Ogbole G, Vaudano A, Wang I, Wang S, Winston G, Rampp S (2024)

Publication Type: Journal article

Publication year: 2024


DOI: 10.1002/epd2.20206


The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Subcortical laminar heterotopia, also known as subcortical band heterotopia (SBH) or “double cortex,” is an intriguing and rare congenital malformation of cortical development. SBH lesions are part of a continuum best designated as agyria-pachygyria-band-spectrum. The malformation is associated with epilepsy that is often refractory, as well as variable degrees of developmental delay. Moreover, in an increasing proportion of cases, a distinct molecular-genetic background can be found. Diagnosing SBH can be a major challenge for many reasons, including more subtle lesions, and “non-classic” or unusual MRI-appearances. By presenting an illustrative case, we address the challenges and needs of diagnosing and treating SBH patients in epilepsy, especially the value of high-resolution imaging and specialized MRI-protocols.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

How to cite


Kasper, B.S., Archer, J., Bernhardt, B.C., Caciagli, L., Cendes, F., Chinvarun, Y.,... Rampp, S. (2024). ILAE neuroimaging task force highlight: Subcortical laminar heterotopia. Epileptic Disorders.


Kasper, Burkhard S., et al. "ILAE neuroimaging task force highlight: Subcortical laminar heterotopia." Epileptic Disorders (2024).

BibTeX: Download