Statin use and longitudinal changes in quantitative MRI-based biomarkers of thigh muscle quality: data from Osteoarthritis Initiative.
Mohajer B, Moradi K, Guermazi A, Dolatshahi M, Roemer FW, Ibad HA, Parastooei G, Conaghan PG, Zikria BA, Wan M, Cao X, Lima JA, Demehri S (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 53
Pages Range: 683-695
Journal Issue: 4
DOI: 10.1007/s00256-023-04473-7
Abstract
OBJECTIVE: To assess whether changes in MRI-based measures of thigh muscle quality associated with statin use in participants with and without/at-risk of knee osteoarthritis. METHODS: This retrospective cohort study used data from the Osteoarthritis Initiative study. Statin users and non-users were matched for relevant covariates using 1:1 propensity-score matching. Participants were further stratified according to baseline radiographic knee osteoarthritis status. We used a validated deep-learning method for thigh muscle MRI segmentation and calculation of muscle quality biomarkers at baseline, 2nd, and 4th visits. Mean difference and 95% confidence intervals (CI) in longitudinal 4-year measurements of muscle quality biomarkers, including cross-sectional area, intramuscular adipose tissue, contractile percent, and knee extensors and flexors maximum and specific contractile force (force/muscle area) were the outcomes of interest. RESULTS: After matching, 3772 thighs of 1910 participants were included (1886 thighs of statin-users: 1886 of non-users; age: 62 ± 9 years (average ± standard deviation), range: 45-79; female/male: 1). During 4 years, statin use was associated with a slight decrease in muscle quality, indicated by decreased knee extension maximum (mean-difference, 95% CI: - 1.85 N/year, - 3.23 to - 0.47) and specific contractile force (- 0.04 N/cm2/year, - 0.07 to - 0.01), decreased thigh muscle contractile percent (- 0.03%/year, - 0.06 to - 0.01), and increased thigh intramuscular adipose tissue (3.06 mm2/year, 0.53 to 5.59). Stratified analyses showed decreased muscle quality only in participants without/at-risk of knee osteoarthritis but not those with established knee osteoarthritis. CONCLUSIONS: Statin use is associated with a slight decrease in MRI-based measures of thigh muscle quality over 4 years. However, considering statins' substantial cardiovascular benefits, these slight muscle changes may be relatively less important in overall patient care.
Involved external institutions
Boston University
United States (USA) (US)
Johns Hopkins University (JHU)
United States (USA) (US)
University of Maryland, Baltimore County
United States (USA) (US)
University of Leeds
United Kingdom (GB)
United States (USA) (US)
Johns Hopkins University (JHU)
United States (USA) (US)
University of Maryland, Baltimore County
United States (USA) (US)
University of Leeds
United Kingdom (GB)
How to cite
APA:
Mohajer, B., Moradi, K., Guermazi, A., Dolatshahi, M., Roemer, F.W., Ibad, H.A.,... Demehri, S. (2024). Statin use and longitudinal changes in quantitative MRI-based biomarkers of thigh muscle quality: data from Osteoarthritis Initiative. Skeletal Radiology, 53(4), 683-695. https://dx.doi.org/10.1007/s00256-023-04473-7
MLA:
Mohajer, Bahram, et al. "Statin use and longitudinal changes in quantitative MRI-based biomarkers of thigh muscle quality: data from Osteoarthritis Initiative." Skeletal Radiology 53.4 (2024): 683-695.
BibTeX: Download