Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer
Damaskos C, Psilopatis I, Garmpi A, Dimitroulis D, Nikolettos K, Vrettou K, Sarantis P, Koustas E, Kouraklis G, Antoniou EA, Karamouzis MV, Nikolettos N, Tsikouras P, Marinos G, Kontomanolis E, Kontzoglou K, Garmpis N (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 16
Article Number: 209
Journal Issue: 1
Abstract
Background/Aim: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer. Materials and Methods: A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the association between HDAC-2 and the survival and clinicopathological features of the patients. Results: Increased HDAC-2 expression was observed in every fourth case of triple negative breast cancer with positive HDAC-2 staining, whereas only 12 out of 98 non-triple negative breast cancer samples showed high HDAC-2 expression. HDAC-2 overexpression correlated with prolonged overall survival (OS) and disease-free survival (DFS) in triple negative breast cancer. Conclusions: High HDAC-2 levels in triple negative breast cancer seem to positively influence patient survival, disease stage and recurrence.
Authors with CRIS profile
Involved external institutions
Laikο General Hospital of Athens
Greece (GR)
Democritus University of Thrace (DUTH) / Δημοκρίτειο Πανεπιστήμιο Θράκης
Greece (GR)
Sismanoglio General Hospital / Γενικό Νοσοκομείο Σισμανόγλειο
Greece (GR)
National and Kapodistrian University of Athens
Greece (GR)
Greece (GR)
Democritus University of Thrace (DUTH) / Δημοκρίτειο Πανεπιστήμιο Θράκης
Greece (GR)
Sismanoglio General Hospital / Γενικό Νοσοκομείο Σισμανόγλειο
Greece (GR)
National and Kapodistrian University of Athens
Greece (GR)
How to cite
APA:
Damaskos, C., Psilopatis, I., Garmpi, A., Dimitroulis, D., Nikolettos, K., Vrettou, K.,... Garmpis, N. (2024). Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer. Cancers, 16(1). https://doi.org/10.3390/cancers16010209
MLA:
Damaskos, Christos, et al. "Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer." Cancers 16.1 (2024).
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