Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer

Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reis-Filho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Adams S, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Chardas A, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Fernandez-Martín C, Fineberg S, Fox SB, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hewitt S, Horlings HM, Husain Z, Irshad S, Janssen EA, Kataoka TR, Kawaguchi K, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Akturk G, Scott E, Kovács A, Lænkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Kharidehal D, Minhas FuAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rajpoot NM, Rapoport BL, Rau TT, Ribeiro JM, Rimm D, Vincent-Salomon A, Saltz J, Sayed S, Hytopoulos E, Mahon S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, Verghese GE, Viale G, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Bartlett J, Loibl S, Denkert C, Savas P, Loi S, Specht Stovgaard E, Salgado R, Gallagher WM, Rahman A (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Book Volume: 262

Pages Range: 271-288

Journal Issue: 3

DOI: 10.1002/path.6238

Abstract

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Authors with CRIS profile

Involved external institutions

GZA Ziekenhuizen Belgium (BE) New York University (NYU) United States (USA) (US) Technical University of Denmark / Danmarks Tekniske Universitet (DTU) Denmark (DK) The Institute of Cancer Research (ICR) United Kingdom (GB) Karolinska Institute Sweden (SE) The National University of Malaysia / Universiti Kebangsaan Malaysia (UKM) Malaysia (MY) University of the Frontier / Universidad de La Frontera (UFRO) Chile (CL) Federal University of Amazonas / Universidade Federal do Amazonas (UFAM) Brazil (BR) University of London United Kingdom (GB) Northwestern University United States (USA) (US) Emory University United States (USA) (US) University College Dublin (UCD) Ireland (IE) Earle A. Chiles Research Institute at the Robert W. Franz Cancer Center United States (USA) (US) Tehran University of Medical Sciences (TUMS) / دانشگاه علوم پزشکی تهران Iran, Islamic Republic of (IR) University of Michigan United States (USA) (US) Vanderbilt University United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Case Western Reserve University United States (USA) (US) Praava Health Bangladesh (BD) Mines ParisTech / École Nationale Supérieure des Mines de Paris (ENSMP) France (FR) Narayana Medical College & Hospital India (IN) University of Washington United States (USA) (US) Yale University United States (USA) (US) University of Warwick United Kingdom (GB) Institut Curie France (FR) Stony Brook Medicine United States (USA) (US) Aga Khan University (AKU) / آغا خان یونیورسٹی‎ Pakistan (PK) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Mayo Clinic Hospital United States (USA) (US) Sunnybrook Health Sciences Centre Canada (CA) University of Pennsylvania (UPenn) United States (USA) (US) ICGA Foundation India (IN) Guy's and St Thomas' (NHS Foundation Trust) United Kingdom (GB) Stavanger University Hospital Norway (NO) Iwate Medical University Japan (JP) Aakash Healthcare Super Speciality Hospital India (IN) Merck & Co., Inc. / Merck Sharp & Dohme Corp (MSD) United States (USA) (US) Georgia Institute of Technology United States (USA) (US) Weill Cornell Medicine United States (USA) (US) University of Surrey United Kingdom (GB) University of British Columbia Canada (CA) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) Centro Medico Nacional Siglo XXI Mexico (MX) Massachusetts General Hospital United States (USA) (US) Stony Brook University (SBU) / SUNY Stony Brook United States (USA) (US) Matsuyama Shimin Hospital / 松山市民病院 Japan (JP) Icahn School of Medicine at Mount Sinai United States (USA) (US) King’s College London United Kingdom (GB) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Mayo Clinic United States (USA) (US) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) National Cancer Institute (NCI) United States (USA) (US) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) F. Hoffmann-La Roche Ltd Switzerland (CH) Bristol-Myers Squibb United States (USA) (US) Institut Jules Bordet Belgium (BE) King Hussein Cancer Center (KHCC) / مركز الحسين للسرطان Jordan (JO) Iuliu Hațieganu University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Iuliu Hațieganu" (UMF Cluj) Romania (RO) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT) University of Edinburgh United Kingdom (GB) Peter MacCallum Cancer Centre Australia (AU) Gentofte Hospital Denmark (DK) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset Sweden (SE) Sjællands Universitetshospital, Roskilde Denmark (DK) National Surgical Adjuvant Breast and Bowel Project Foundation (NSABP) United States (USA) (US) Manipal Hospitals India India (IN) University College Hospital United Kingdom (GB) Hospital Clínico Universitario de Valencia Spain (ES) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) Hospital Universitário Getúlio Vargas (HUGV) Brazil (BR) Polytechnic University of Valencia / Universidad Politécnica de Valencia Spain (ES) Albert Einstein College of Medicine United States (USA) (US) The University of Melbourne Australia (AU) Genentech Inc. United States (USA) (US) University College London (UCL) United Kingdom (GB) Ziauddin University (ZU) Pakistan (PK) All India Institute of Medical Sciences Raipur (AIIMS) / अखिल भारतीय आयुर्विज्ञान संस्थान रायपुर India (IN) University of Birmingham United Kingdom (GB) Imagerie Moléculaire et Stratégies Théranostiques (IMoST) France (FR) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT) Medical Oncology Centre of Rosebank South Africa (ZA) Universitätsklinikum Düsseldorf Germany (DE) Institut Gustave-Roussy France (FR) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Mater Misericordiae University Hospital (MMUH) / Ospidéal an Mater Misercordiae Ireland (IE) Universitätsklinikum Heidelberg Germany (DE) University of Texas MD Anderson Cancer Center United States (USA) (US) Kyoto University / 京都大学 Kyōto daigaku Japan (JP) Tempus Labs United States (USA) (US) CellCarta Canada (CA) Fudan University / 复旦大学 China (CN) Philipps-Universität Marburg Germany (DE)

How to cite

APA:

Jahangir, C.A., Page, D.B., Broeckx, G., Gonzalez, C.A., Burke, C., Murphy, C.,... Rahman, A. (2024). Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 262(3), 271-288. https://doi.org/10.1002/path.6238

MLA:

Jahangir, Chowdhury Arif, et al. "Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 262.3 (2024): 271-288.

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