Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection

Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé VV, Riedmann S, Ugur M, Imdahl F, Rosshart SP, Arnold SJ, Gomez de Agüero M, Gagliani N, Flavell RA, Backes S, Kastenmüller W, Gasteiger G (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Immunity Elsevier

Book Volume: 57

Pages Range: 124-140.e7

Journal Issue: 1

DOI: 10.1016/j.immuni.2023.11.018

Abstract

Natural killer (NK) cells are present in the circulation and can also be found residing in tissues, and these populations exhibit distinct developmental requirements and are thought to differ in terms of ontogeny. Here, we investigate whether circulating conventional NK (cNK) cells can develop into long-lived tissue-resident NK (trNK) cells following acute infections. We found that viral and bacterial infections of the skin triggered the recruitment of cNK cells and their differentiation into Tcf1hiCD69hi trNK cells that share transcriptional similarity with CD56brightTCF1hi NK cells in human tissues. Skin trNK cells arose from interferon (IFN)-γ-producing effector cells and required restricted expression of the transcriptional regulator Blimp1 to optimize Tcf1-dependent trNK cell formation. Upon secondary infection, trNK cells rapidly gained effector function and mediated an accelerated NK cell response. Thus, cNK cells redistribute and permanently position at sites of previous infection via a mechanism promoting tissue residency that is distinct from Hobit-dependent developmental paths of NK cells and ILC1 seeding tissues during ontogeny.

Authors with CRIS profile

Stephan Patrick Rosshart Professur für Mikrobiomik

Additional Organisation(s)

FAU Profilzentrum Licht.Materie.Quantentechnologien (FAU LMQ)

Involved external institutions

Julius-Maximilians-Universität Würzburg DE Germany (DE) Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) DE Germany (DE) Albert-Ludwigs-Universität Freiburg DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Yale School of Medicine US United States (USA) (US)

How to cite

APA:

Torcellan, T., Friedrich, C., Doucet-Ladevèze, R., Ossner, T., Solé, V.V., Riedmann, S.,... Gasteiger, G. (2024). Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection. Immunity, 57(1), 124-140.e7. https://dx.doi.org/10.1016/j.immuni.2023.11.018

MLA:

Torcellan, Tommaso, et al. "Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection." Immunity 57.1 (2024): 124-140.e7.

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