A framework for standardised tissue sampling and processing during resection of diffuse intracranial glioma: joint recommendations from four RANO groups

Karschnia P, Smits M, Reifenberger G, Le Rhun E, Ellingson BM, Galldiks N, Kim MM, Huse JT, Schnell O, Harter PN, Mohme M, Aldape K, Baehring JM, Bello L, Brat DJ, Cahill DP, Chung C, Colman H, Dietrich J, Drummond K, Esquenazi Y, Gerstner ER, Furtner J, Garibotto V, Kaufmann TJ, Komori T, Kotecha R, Liau LM, Lupo JM, Minniti G, Narita Y, Niyazi M, Perry A, Preusser M, Rudà R, Sanai N, Schmidt NO, Steinbach JP, Thust SC, Tolboom N, van der Hoorn A, van der Vaart T, Verger A, Vik-Mo EO, Watts C, Westphal M, Wesseling P, Young JS, von Baumgarten L, Albert NL, Huang RY, Mehta MP, van den Bent M, Weller M, Vogelbaum MA, Chang SM, Berger MS, Tonn JC (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Lancet Oncology Elsevier: Lancet

Book Volume: 24

Pages Range: e438-e450

Journal Issue: 11

DOI: 10.1016/S1470-2045(23)00453-9

Abstract

Surgical resection represents the standard of care for people with newly diagnosed diffuse gliomas, and the neuropathological and molecular profile of the resected tissue guides clinical management and forms the basis for research. The Response Assessment in Neuro-Oncology (RANO) consortium is an international, multidisciplinary effort that aims to standardise research practice in neuro-oncology. These recommendations represent a multidisciplinary consensus from the four RANO groups: RANO resect, RANO recurrent glioblastoma, RANO radiotherapy, and RANO/PET for a standardised workflow to achieve a representative tumour evaluation in a disease characterised by intratumoural heterogeneity, including recommendations on which tumour regions should be surgically sampled, how to define those regions on the basis of preoperative imaging, and the optimal sample volume. Practical recommendations for tissue sampling are given for people with low-grade and high-grade gliomas, as well as for people with newly diagnosed and recurrent disease. Sampling of liquid biopsies is also addressed. A standardised workflow for subsequent handling of the resected tissue is proposed to avoid information loss due to decreasing tissue quality or insufficient clinical information. The recommendations offer a framework for prospective biobanking studies.

Authors with CRIS profile

Oliver Schnell

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) University of Michigan Hospital US United States (USA) (US) University of Texas MD Anderson Cancer Center US United States (USA) (US) Universitätsklinikum Freiburg DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Erasmus University Medical Center (MC) NL Netherlands (NL) Heinrich-Heine-Universität Düsseldorf DE Germany (DE) Universitätsspital Zürich (USZ) CH Switzerland (CH) University of California Los Angeles (UCLA) US United States (USA) (US) University of California San Francisco (UCSF) US United States (USA) (US) Brigham and Women's Hospital (BWH) US United States (USA) (US) Baptist Health South Florida US United States (USA) (US) H. Lee Moffitt Cancer Center & Research Institute US United States (USA) (US)

How to cite

APA:

Karschnia, P., Smits, M., Reifenberger, G., Le Rhun, E., Ellingson, B.M., Galldiks, N.,... Tonn, J.C. (2023). A framework for standardised tissue sampling and processing during resection of diffuse intracranial glioma: joint recommendations from four RANO groups. Lancet Oncology, 24(11), e438-e450. https://dx.doi.org/10.1016/S1470-2045(23)00453-9

MLA:

Karschnia, Philipp, et al. "A framework for standardised tissue sampling and processing during resection of diffuse intracranial glioma: joint recommendations from four RANO groups." Lancet Oncology 24.11 (2023): e438-e450.

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